Background: Mechanical neck dysfunction (MND) is a disabling and costly disorder. There are insufficient data available to determine the efficacy of the stabilization and McKenzie exercises on MND.Purpose: The objective of this study was to compare stabilization exercises to McKenzie exercises in patients with MND.Design: Two group pretest-posttest design.Materials and Methods: Twenty-seven participants were randomly allocated to the stabilization group (n=14) and the McKenzie group (n=13). Each group received treatment twice a week over a 6-week period. Outcome included pain intensity measured on a visual analogue scale, disability measured with the neck disability index, pain threshold measured with the pressure algometer and cervical range of motion measured with an electronic goniometer at baseline and after six weeks of treatment.Results: Pain intensity, functional disability, pain threshold and cervical range of motion showed significant differences in all groups after intervention. However, there were no significant differences between groups.Conclusion: Within the limitations of this study, both programs were equally effective in improving pain, disability, and range of motion of patients with MND.