2012
DOI: 10.1016/j.joen.2011.10.015
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The Effect of Matrix Extracellular Phosphoglycoprotein and Its Downstream Osteogenesis-related Gene Expression on the Proliferation and Differentiation of Human Dental Pulp Cells

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Cited by 17 publications
(8 citation statements)
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“…We have shown that mouse molars with ablated Mepe exhibited reduced levels of other SIBLING transcripts as well as decreased levels of Enam , suggesting dysregulation of critical dentin and enamel matrix proteins that are essential for normal mineralization. These findings support previous in vitro studies where the overexpression of MEPE in dental pulp cells caused increased levels of odontoblast markers BSP, DSP (DSPP), and collagen type I and Enam (Wei et al 2012). Interestingly, Enam is a member of the SCPPs, which are rich in Pro and Gln (P/Q) and associated with enamel mineralization, located on 4q21 adjacent to the SIBLING gene cluster (Kawasaki 2011).…”
Section: Discussionsupporting
confidence: 91%
“…We have shown that mouse molars with ablated Mepe exhibited reduced levels of other SIBLING transcripts as well as decreased levels of Enam , suggesting dysregulation of critical dentin and enamel matrix proteins that are essential for normal mineralization. These findings support previous in vitro studies where the overexpression of MEPE in dental pulp cells caused increased levels of odontoblast markers BSP, DSP (DSPP), and collagen type I and Enam (Wei et al 2012). Interestingly, Enam is a member of the SCPPs, which are rich in Pro and Gln (P/Q) and associated with enamel mineralization, located on 4q21 adjacent to the SIBLING gene cluster (Kawasaki 2011).…”
Section: Discussionsupporting
confidence: 91%
“…Whereas CST6 expression was downregulated in Finnsheep and the F1 crosses compared with Texel, the flushing diet appeared to minimize the expression of this gene in Texel, because it was downregulated in the Texel group receiving the flushing diet (within breed diet comparisons). To date, studies examining the functional aspects of MEPE have focused on humans and have highlighted a role in bone proliferation and differentiation [ 31 33 ]. Both CST6 and MEPE were downregulated in Finnsheep and upregulated in Texel.…”
Section: Resultsmentioning
confidence: 99%
“…Another study examined the protein MEPE. Obviously, the protein plays an important role in the proliferation and osteogenic differentiation of dental pulp cells [37].…”
Section: Discussionmentioning
confidence: 99%