The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam

Abstract

Background. Maternal vaccination with an acellular pertussis (aP)–containing vaccine is a recommended strategy in a growing number of industrialized countries, to protect young infants from disease. Little is known on the effect of this strategy in low- and middle-income countries. Following a previous report on the effect of adding a pertussis and diphtheria component to the tetanus vaccination program in pregnant women in Vietnam, we report on infant immune responses to a booster aP vaccine dose in this randomized controlled clinical trial.Methods. Thirty infants of Tdap (tetanus, diphtheria, and acellular pertussis)–vaccinated pregnant women and 37 infants of women vaccinated with a tetanus-only vaccine received a fourth aP-containing vaccine dose in the second year of life. Blood was taken 1 month after the fourth infant dose. Immunoglobulin G (IgG) antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Prn), tetanus toxoid (TT), and diphtheria toxoid (DT) were measured using commercially available enzyme-linked immunosorbent assays (ELISA).Results. One month after the booster dose, significantly lower antibody titers were measured in the Tdap group for anti-TT IgG (P < .001) only. Anti-DT IgG, anti-PT IgG, anti-Prn IgG, and anti-FHA IgG antibody titers were comparable for both groups. A rise in antibody concentrations was elicited for all (except DT) antigens after boosting.Conclusions. The present results indicate that the blunting of infant pertussis responses induced by maternal immunization, measured after a primary series of aP vaccines, was resolved with the booster aP vaccine dose. These results add to the evidence for national and international decision makers on maternal immunization as a vaccination strategy for protection of young infants against infectious diseases.

The Economic Evaluation in Vaccines - A Systematic Review in Vietnam Situation

“…15,17,18,19 In the absence of a scientific basis for the cost effectiveness of vaccines, the policy makers in Vietnam may depend heavily on the research is published and available presentations unpublished real by industry or academic researchers. [20][21][22] With unfiltered potential impact of literature on decision making, we set out to implement a system of economic assessment is published in the vaccine in Vietnam. Our objective is critically comprehensive review on vaccine research, funding, quality of research, changes over time, and a summary of their main findings.…”

Expected challenges of implementing universal pertussis vaccination during pregnancy in Quebec: a cross-sectional survey

“…6,30 In countries such as the UK that have achieved higher coverage (about 70%) for Tdap vaccination during pregnancy, 31 vaccines are commonly administered in the physician's office. 9,32 It is important to note that many pregnant women in the UK receive care within the context of a general medical clinic that stocks vaccines. This suggests that the ability to vaccinate at the point of prenatal care may facilitate implementation of universal maternal vaccination.…”

Maternal pertussis immunisation: clinical gains and epidemiological legacy

“…Studies of antibody titres after the fourth booster dose, however, found no effect of maternal immunisation history [18,20,24]. There may be two not mutually exclusive explanations for this finding: the absence of MatAb in 12–18-month-olds due to waning [12,14], and the successful boosting effect of the fourth dose, leading to antibody titres similar to control individuals.…”