The effect of maternal pertussis vaccination on the epidemiology of pertussis in Spain

The Present and Future Aspects of Life-Long Pertussis Prevention: Narrative Review with Regional Perspectives for Türkiye

“…Similarly, during the pertussis resurgence in the UK in 2012, the highest incidence of pertussis was seen in infants \ 3 months old whereas a remarkable rise was also reported in the age cohort of [ 15 years [43]. In Spain, infants \ 3 months of age accounted for almost 60% of hospitalizations due to pertussis, and [ 90% of hospitalized patients were infants\1 year of age [44]. Mortality rates in infants \ 3 months old were the highest in all these epidemics [45].…”

“…Pertussis vaccination in pregnancy was available in all regions of Spain in early 2016. While the national mean of death from pertussis was 5.1 per year between 2007 and 2015, annual mortality rate fell to 2.5 per year between 2016 and 2019 [44].…”

“…Mortality rates in infants \ 3 months old were the highest in all these epidemics [45]. In addition, the most recent data show that pertussis remains an important cause for deaths in infants and young children [20,44]. Thus, when implementing elimination plans for pertussis, it is essential to develop routes that stop pertussis dissemination among both newborns and young infants.…”

“…Pertussis can cause especially severe disease in newborns and unvaccinated infants [44]. A study conducted in Tu ¨rkiye reviewed 18 patients in a pediatric intensive care unit with a diagnosis of pertussis, all of whom were unvaccinated.…”

“…Pertussis is a remarkable cause of morbidity and mortality in children, particularly in infants \ 6 months of age via transmission from a relative in close contact [20,44]. Generally, the initial pertussis vaccine is given at the age of 6 or 8 weeks but can be delayed up to 3 months in several countries [1].…”