The effect of maternal anaemia on low birth weight among newborns in Northwest Ethiopia

Engidaw, Melaku Tadege; Eyayu, Tahir; Tiruneh, Tegenaw

doi:10.1038/s41598-022-19726-z

Cited by 7 publications

(6 citation statements)

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“…The drop in maternal hemoglobin concentration may then impact fetal birth weight. This finding is consistent with other studies' findings [ 8 , 23 ]. This could be a result of intrauterine development limitation.…”

Section: Discussionsupporting

confidence: 94%

Maternal and Neonatal Outcomes of Iron Deficiency Anemia: A Retrospective Cohort Study

Safarzadeh,

Banihashemi,

Montazeri

et al. 2023

Cureus

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Introduction: Understanding the outcomes of anemia in pregnancy is critical. Since no study has been conducted regarding the maternal and neonatal outcomes of iron-deficiency anemia in Hormozgan province of Iran, this study aims to assess the maternal and neonatal outcomes of iron-deficiency anemia in women who gave birth in Hormozgan province from January 2020 to January 2022. Methods: We retrospectively assessed all singleton pregnant women who gave birth at a tertiary hospital in Bandar Abbas, Hormozgan province, Iran, for two years. We divided all women into iron-deficiency anemic and non-iron-deficiency anemic women. Iron-deficiency anemia was defined as hemoglobin less than 10.5 mg/dl at the time of admission without any other hemoglobinopathy, such as sickle cell anemia or thalassemia. Using electronic patient records, data were extracted from the Iranian Maternal and Neonatal Network (IMaN Net), a valid national system. Since the information of birth under 24 weeks of gestation is not recorded in this system, we excluded all deliveries under 24 weeks of gestation. The outcome measures of the study were demographic factors (age, education, residency place, access to prenatal care, smoking), obstetrical factors (parity, labor induction, fetal presentation, mode of delivery), and maternal and neonatal outcomes (the incidence of preeclampsia, gestational diabetes, placenta abruption, postpartum hemorrhage, maternal need for blood transfusion, maternal need for intensive care unit, preterm birth, low birth weight, intrauterine growth retardation, birth asphyxia, stillbirth, and neonatal intensive care admission). Chi-square tests were used to compare differences between iron-deficiency anemic and non-iron-deficiency anemic women. Logistic regression models were used to assess the effect of iron-deficiency anemia on maternal and neonatal outcomes. The result was presented as odds ratio (OR) or adjusted odds ratio (aOR) after adjusting for covariates and a 95% confidence interval (CI). Results: The incidence of iron-deficiency anemia was 2.97%. Education and residency were among the demographic factors that differed significantly between groups. Iron-deficiency anemia was more frequent in those with higher education and women who lived in rural areas. In terms of obstetrical factors, method of delivery was the only significantly different factor between groups. Iron-deficiency anemic mothers had substantially more instrumental deliveries than non-iron-deficiency anemic mothers (4.3% vs. 0.8%), while the incidence of cesarean section was lower. Based on logistic regression in terms of maternal and neonatal outcomes, iron-deficiency anemic women had a substantially higher risk of the need for maternal blood transfusion (aOR: 6.54, 95%CI: 4.72-8.15), postpartum hemorrhage (aOR: 1.54, 95%CI: 0.71-2.11), preterm birth (aOR: 0.98, 95%CI: 0.45-1.13), low birth weight (aOR: 1.04, 95%CI: 0.78-2.01), intrauterine growth retardation (aOR: 1.30, 95%CI: 0.99-2.10), and neonatal intensive care admi...

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Section: Discussionsupporting

confidence: 94%

Maternal and Neonatal Outcomes of Iron Deficiency Anemia: A Retrospective Cohort Study

Safarzadeh,

Banihashemi,

Montazeri

et al. 2023

Cureus

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“…37 Anemia is an adverse issue during pregnancy and negatively impacts the outcomes for the newborn, including fetal anemia, stillbirth, and low and very low birth weights. 38,39 On the other hand, obstructed fetal growth brought on by maternal anemia raises the possibility of birth stunting. 40 Our results on the impact of maternal anemia on infants are consistent with earlier studies.…”

Section: Discussionmentioning

confidence: 99%

Nutritional status of Vietnamese infants assessed by Fenton growth chart and related factors: A cross‐sectional study

Nguyen,

Tran,

Nguyen

et al. 2023

Pediatric Investigation

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ImportanceNutritional status of infants, measured by birth weight and length, is an essential factor in neonatal development. Malnutrition in newborns may lead to a higher risk of mortality, neurological and cognitive impairment, and poor language development.ObjectiveThis study aims to assess the nutritional status of infants and related factors regarding maternal anthropometric characteristics and medical history.MethodsA cross‐sectional study was conducted at the National Hospital of Obstetrics and Gynecology, Vietnam from May 2021 to May 2022 on 340 infants and mothers. Low birth weight was defined following the Intergrowth‐21 standards. Stunting was evaluated using the Fenton growth chart when the length was below the 10% percentile line of the gestational week. Multivariate regression models were applied to identify factors associated with the nutritional status of infants.ResultsWe found that 12.4% and 14.1% of infants in our study fell into stunted and underweight categories, respectively. Infants of mothers over 35 years old, having a height lower than 150 cm or experiencing anemia during pregnancy were more likely to be stunted or have low birth weight. Serum albumin deficiency during pregnancy was strongly associated with the infant being underweight (odds ratio [OR] = 2.8, 95% confidence interval [95%CI] 1.1–7.3). Newborns were more likely to be stunted if their mothers had a history of preterm birth (OR = 3.3, 95%CI 1.1–10.2).InterpretationMaternal nutritional status is closely related to infant malnutrition, particularly in preterm infants. Improving the understanding of mothers regarding prenatal care, reproductive healthcare, adequate nutritional diet, and multi‐micronutrient supplements during pregnancy is therefore important.

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“…In this present study, women who were anemic at term were likely to give birth to LBW neonates. Previous studies conducted in LMICs con rm that there is a positive association between maternal anemia and LBW either during late pregnancy or at term LBW [75][76][77]. It is reasonable that maternal anemia increases the risk of LBW because maternal anemia characterized by reduced levels of hemoglobin favor changes in placental blood supply, limiting the availability of oxygen and nutrients to the fetus and, consequently leading to intrauterine fetal growth restriction, a predictor of LBW [39].…”

Section: Maternal Anemia At Term and Low Birth Weightmentioning

confidence: 99%

Maternal socio-demographic, medical and nutritional predictors of low birth weight neonates delivered in a civil unrest setting: A case study of Bosaso general hospital, North Eastern Somalia

Buzigi

Mohammed

2023

Preprint

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Background Low birth weight (LBW) defined as a newborn weighing less than 2.5 kilograms (kg) is a leading predictor of morbidity and mortality in either childhood or adulthood. The prevalence and predictors of LBW in Somalia are scarce. This study determined the maternal socio-demographic, medical, and nutritional predictors of delivering LBW neonates in Bosaso Hospital, Somalia. Methods This cross-sectional study of 1074 randomly selected mothers who delivered babies in Bosaso general Hospital from November 2022 to April 2023. A neonate was considered to be LBW if it weighed less than 2.5kg. Data for predictor variables were collected from mothers or by reviewing antenatal and postnatal registers. The association between predictor variables and LBW was tested by multivariate logistic regression analysis using STATA 15 by reporting an adjusted odds ratio (AOR) and 95% confidence interval (CI). A statistical test was considered significant at p < 0.05. Results The prevalence of LBW was 18%. Mothers with the following social demographic characteristics were likely to deliver LBW neonates: teenagers, AOR 1.3 (95%CI:1.2–1.5); residing in internally displaced persons (IDP) camp, AOR 1.2(95% C1:1-1.9); no formal education, AOR 1.4(95%CI:1.2–1.5); unemployed, AOR 1.2(95%CI:1.1–1.3); divorced, AOR 1.3 (95% CI:1.1–1.4); and widowed, AOR 1.3 (95%CI:1.2–1.5). Women with the following medical factors were likely to deliver LBW neonates: having less than 8 ANC visits, AOR 1.2 (95%CI:1.1–1.5); primigravida, AOR1.2 (95%CI:1.1–1.6), history of delivering a LBW, AOR 1.2 (95% CI:1.1–1.4); history of preterm birth, AOR 1.6(1.3–1.8); birth interval less than 3 years, AOR 1.2(95% CI: 1.3–1.4); malaria during pregnancy, AOR 1.3(95%CI:1.1–1.6). Women with the following medical factors were less likely to deliver LBW neonates: Having the 1st ANC visit in the 1st trimester, AOR 0.6(0.3–0.7); using an insecticide-treated mosquito net, AOR 0.5(95%CI: 0.2–0.6); swallowed sulfadoxine-pyrimethamine under directly observed treatment (DOT), AOR 0.6 (95% CI: 0.2–0.8), and DOT with deworming tablets, AOR 0.6(95%CI:0.2–0.7). Mothers with the following nutritional characteristics were likely to deliver LBW neonates: maternal height < 150cm, AOR 1.2 (95% CI: 1.1–1.3); anemia at full term, AOR 1.4(95%CI: 1.3–1.7); mid-upper arm circumference < 23 cm, AOR 2.1(95% CI: 1.2–2.3). Mothers who received iron-folic acid supplementation, AOR 0.4(95%CI: 0.2–0.7), had a lower risk of delivering LBW neonates. Conclusion In Bosaso general hospital, delivering a LBW neonate was likely to be among pregnant mothers who: were teenagers, stunted, residing in IDP camps, unemployed, divorced or widowed, primigravida, had attended < 8 ANC visits, no formal education, with a history of preterm birth or LBW, birth interval < 3years, malaria during pregnancy, were anemia and wasted at term.

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The effect of maternal anaemia on low birth weight among newborns in Northwest Ethiopia

Cited by 7 publications

References 50 publications

Maternal and Neonatal Outcomes of Iron Deficiency Anemia: A Retrospective Cohort Study

Maternal and Neonatal Outcomes of Iron Deficiency Anemia: A Retrospective Cohort Study

Nutritional status of Vietnamese infants assessed by Fenton growth chart and related factors: A cross‐sectional study

Maternal socio-demographic, medical and nutritional predictors of low birth weight neonates delivered in a civil unrest setting: A case study of Bosaso general hospital, North Eastern Somalia

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