The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes

Ochocka, Renata; Hering, Anna; Stefanowicz–Hajduk, Justyna; Cal, Krzysztof; Baranska, Helena

doi:10.1371/journal.pone.0181542

Cited by 46 publications

(59 citation statements)

References 35 publications

(35 reference statements)

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“…[52] Previous studies reported that F I G U R E 4 EDX spectrum of Ag nanoparticles F I G U R E 5 Anticancer assay of AgNWs mediated green synthesis silver nanoparticles HeLa and HT-29 cell lines phenolic compounds such as caffeine, catechin, epigallocatechin gallate, and mangiferin has inhibited ChC enzyme activity depending on various concentrations. [53][54][55][56][57]…”

Section: Effect Of Agnws On Collagenase Activitymentioning

confidence: 99%

Synthesis of silver nanowires in a two‐phase system for biological applications

Korkmaz

Akar

İmamoğlu

et al. 2021

Applied Organom Chemis

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The ability to design nanowires (NW) in powder technology provides a great advantage for many applications in a variety of fields ranging from medicine to materials science. In this study, nanoparticles were synthesized simultaneously by using an aqueous two‐phase system, which was an environmentally friendly method since the reducing agent that was not spent in the reaction could be effectively recycled and reused. AgNWs (silver nanowires) with numerous high widths and dyes were easily synthesized between two phases using the 5,8‐dibromo‐2‐(butylamino)naphthalene‐1,4‐dione, a 2‐substituted naphthoquinone. Naphthoquinones are known as reducing agents in the production of metal nanoparticles. Synthesized NWs have an average diameter of 90 nm and an average length of 6 μm. The nanowires produced had a round cross section. Characterization of nanowires and nanoparticles was done with UV‐vis, XRD pattern, SEM, and EDX. As a result of characterization, it showed two relatively sharp absorbances in the UV‐vis spectrum at a wavelength of ~358 and 432 nm. In the XRD analysis, five basic peaks attributed to Ag nanoparticles were observed. When SEM images were analyzed, it was determined that Ag nanowires generally have an average diameter of 90 nm and an average length of 6 μm. Anticancer activity test was performed using the MTT test in the HeLa and HT‐29 cell lines. IC50 value was calculated as 11.54 and 16.07 μg ml, and AgNWs showed anticancer properties at high concentration. Evaluating the influence of AgNWs for the first time, this study has indicated that AgNWs exhibit inhibitory properties on the collagenase enzyme. It was observed that the IC50 rate for the enzyme activity was 346.5 mM (r2: 0.955), and Ki value was 41.09 mM.

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Section: Effect Of Agnws On Collagenase Activitymentioning

confidence: 99%

Synthesis of silver nanowires in a two‐phase system for biological applications

Korkmaz

Akar

İmamoğlu

et al. 2021

Applied Organom Chemis

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“…The main barrier for xenobiotic absorption through the skin is the stratum corneum. Research has revealed the ability of mangiferin to reversibly inhibit elastase and collagenase activity, as well as to permeate the stratum corneum and pass into the epidermis and dermis (115). As the fat and water distribution coefficient of mangiferin is relatively high, oral absorption is low (9), which suggests that mangiferin may be better absorbed through the skin.…”

Section: Other Properties Of Mangiferinmentioning

confidence: 99%

Mangiferin: An effective therapeutic agent against several disorders (Review)

Liu

Lei

et al. 2018

Mol Med Report

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Mangiferin (1,3,6,7-tetrahydroxyxanthone-C2-β-Dglucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, anti-hyperuricemic, neuroprotective, antioxidant, anti-inflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several health-endorsing properties and is a promising candidate for further research and development. However, low solubility, mucosal permeability and bioavailability restrict the development of mangiferin as a clinical therapeutic, and chemical and physical modification is required to expand its application. This review comprehensively analyzed and collectively summarized the primary pharmacological actions of mangiferin that have been demonstrated in the literature, to support the potential future development of mangiferin as a novel therapeutic drug. Contents 1. Introduction 2. Potential application of mangiferin in antidiabetic therapy 3. Anti-tumor effects of mangiferin 4. The neuroprotective properties of mangiferin 5. Cardiovascular effects of mangiferin 6. Other properties of mangiferin 7. Conclusions

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“…e precision and accuracy were analyzed by the QC samples at three concentrations (3,160, and 480 ng/mL). e intraday and interday precision and accuracy were determined by analyzing six replicates of plasma samples on the same day and three consecutive days, respectively.…”

Section: Precision and Accuracymentioning

confidence: 99%

“…Mangiferin (MG, Figure 1), 1,3,6,7-tetrahydroxyxanthone-C2-β-D glucoside, is a type of xanthone derivative found in Mangifera indica L., Anemarrhena asphodeloides Bunge, and other plants [1][2][3][4][5]. Recent studies showed that MG has multiple beneficial biological activities, including antidiabetes, antioxidation, antitumor, anti-inflammation, immunoregulation, antipyretic, antibacterial, memory improvement, and prevention of ultraviolet-induced skin aging [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Comparisons of Mangiferin and Mangiferin Monosodium Salt in Rat Plasma by UPLC-MS/MS

Guo

Chen

et al. 2019

Journal of Chemistry

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Mangiferin (MG) is an active component in natural medicines, and various studies have been reported on pharmacological effects, but the low solubility and bioavailability of MG limit its wide application. The aim of the present study was to investigate the pharmacokinetic profiles of mangiferin (MG) and mangiferin monosodium salt (MG-Na) in rat plasma by UPLC-MS/MS, which were then compared between the two groups. An appropriate high sensitivity and selectivity ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to the comparison of plasma pharmacokinetics in MG and MG-Na using carbamazepine as internal standard (IS). These results showed that there were statistically significant differences in the pharmacokinetic parameters between MG and MG-Na after a single oral administration at 100 mg/kg. When compared with pharmacokinetic parameters of MG, the AUC(0-t), AUC(0–∞), Cmax,K10, and Ka of MG-Na were increased by 5.6-, 5.7-, 20.8-, 8-, and 83.6-fold, while the Tmax and CL/F were decreased by 4- and 5.7-fold (P<0.001), respectively. t1/2 value showed an increasing trend, but was statistically significant between the two groups. Moreover, the AUC value in the MG-Na group was significantly increased and the relative bioavailability was calculated to be 570% when compared with that of the MG group. These results suggested that the salification reaction of MG can effectively enhance gastrointestinal absorption and relative bioavailability by improving solubility and membrane permeability.

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The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes

Cited by 46 publications

References 35 publications

Synthesis of silver nanowires in a two‐phase system for biological applications

Synthesis of silver nanowires in a two‐phase system for biological applications

Mangiferin: An effective therapeutic agent against several disorders (Review)

Pharmacokinetic Comparisons of Mangiferin and Mangiferin Monosodium Salt in Rat Plasma by UPLC-MS/MS

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