The Effect of Malaria on Biochemical Liver Function Parameters in Sudanese Pregnant Women

Elbadawi, Nour Eldaim Elnoman; Mohamed, Maha Ismail; Elzaki, Hamdan; Ounsa, Mohamed Ahmed A/Gadir Elimam; Mohamed, Elsadig Yousif; Ibrahim, Elwathiq K

doi:10.4172/2324-8793.1000101

“…Nevertheless, there was no noteworthy correlation seen between malaria infection and factors such as age, gravidity, parity, sodium, and potassium. Nevertheless, research done in Sudan [23] had comparable results to those obtained in our study. The bulk of the cases occurred during the second and third trimesters, whereas most of the controls were in the first and second trimesters.…”

Section: Discussionsupporting

confidence: 89%

Untitled

2024

Int. J. Mosq. Res.

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The aim of the present study was to assess the effect of malaria on renal function of pregnant women receiving antenatal care. Methods: This hospital-based case-control study was carried out for the period of one year. A total of 200 patients (100 with gestational malaria as cases and 100 healthy pregnant women as controls) were recruited for this study. Results: Gestational age, urea, and creatinine were associated with malaria infection. However, age, gravidity, parity, sodium, and potassium showed no significant association with malaria infection. There were significantly increased plasma urea and creatinine with respect to increasing degree of parasitaemia (moderate and high) com-pared to non-malaria group. There was a significant difference in levels of urea and creatinine and the degree of parasitaemia when stratified according to the gestational age. However, parity and gravidity showed no significance difference. Conclusion:We concluded that malaria has a significant impact on renal biochemical profile (most importantly, urea and creatinine), with cases of increasing gestational age having a higher risk of the consequences of malaria. We recommend that pregnant women who report to hospitals with malaria should also be examined for kidney function.

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“…Nevertheless, there was no noteworthy correlation seen between malaria infection and factors such as age, gravidity, parity, sodium, and potassium. Nevertheless, research done in Sudan [23] had comparable results to those obtained in our study. The bulk of the cases occurred during the second and third trimesters, whereas most of the controls were in the first and second trimesters.…”

Section: Discussionsupporting

confidence: 89%

A hospital based analytical study evaluating renal function in pregnant women with malaria

Nagarik

2024

Int. J. Mosq. Res.

0

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The aim of the present study was to assess the effect of malaria on renal function of pregnant women receiving antenatal care. Methods: This hospital-based case-control study was carried out for the period of one year. A total of 200 patients (100 with gestational malaria as cases and 100 healthy pregnant women as controls) were recruited for this study. Results: Gestational age, urea, and creatinine were associated with malaria infection. However, age, gravidity, parity, sodium, and potassium showed no significant association with malaria infection. There were significantly increased plasma urea and creatinine with respect to increasing degree of parasitaemia (moderate and high) com-pared to non-malaria group. There was a significant difference in levels of urea and creatinine and the degree of parasitaemia when stratified according to the gestational age. However, parity and gravidity showed no significance difference. Conclusion:We concluded that malaria has a significant impact on renal biochemical profile (most importantly, urea and creatinine), with cases of increasing gestational age having a higher risk of the consequences of malaria. We recommend that pregnant women who report to hospitals with malaria should also be examined for kidney function.

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“…PAM is characterized by modification to maternal physiological and biochemical state. Anaemia [14], interference with liver activity [15], depletion of essential micro-and macro-nutrients [16,17] and alteration of plasma lipid and protein profile [10,18,19] are effects attributable to malaria during pregnancy. Rupturing and dysfunctional modification of infected RBC by the blood dwelling erythrocytic stage of Plasmodium parasite, the merozoites, depletes cumulative available RBC surface areas and haemoglobin needed for oxygen transport.…”

Section: Effects Of Malaria To Pregnant Women Foetus and Neonatesmentioning

confidence: 99%

Pregnancy-associated Malaria, Challenges and Prospects in Sub-Saharan Africa

Aguzie¹

2018

Clinics Mother Child Health

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Pregnancy-associated malaria remains a major risk to the pregnant woman, her foetus and infants in sub-Saharan Africa. Infection by Plasmodium falciparum significantly affects maternal, foetal and neonatal wellbeing. Maternal anaemia, low birth weight, preterm labour, spontaneous abortion, and maternal and neonatal mortalities are some of its consequences. It complicates maternal immunological responses and possibly also selfishly preempts foetal immunological responses by transplacental communications. Therefore, the impacts may extend well beyond the duration of pregnancy and the immediate period post-delivery. Effective case management and prevention continue to yield positive results, but challenges still remains especially in sub-Saharan Africa. The challenges of antenatal service provision, compliance with intermittent preventive treatment at pregnancy with sulfadoxine-pyrimethamine (IPTp-SP), widespread SP resistance, and resistance to insecticide treated nets (ITNs) and insecticides continue to complicate efforts at PAM control in sub-Saharan Africa. Hopefully, the Global Technical Strategy for Malaria 2016-2030 will comprehensively consider these challenges and improve the prospect of every pregnant woman in sub-Saharan Africa.

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The Effect of Malaria on Biochemical Liver Function Parameters in Sudanese Pregnant Women

Cited by 4 publications

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A hospital based analytical study evaluating renal function in pregnant women with malaria

Pregnancy-associated Malaria, Challenges and Prospects in Sub-Saharan Africa

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