The effect of magnesium sulfate on surgical field during endoscopic sinus surgery

Abstract

Introduction: The benefits of magnesium sulfate for surgical field during endoscopic sinus surgery remain controversial. We conduct a systematic review and meta-analysis to explore the influence of magnesium sulfate versus placebo on surgical field during endoscopic sinus surgery. Methods: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2018 for randomized controlled trials (RCTs) assessing the effect of magnesium sulfate versus placebo on surgical field during endoscopic sinus surgery. This meta-analysis is performed using the random-effect model. Results: Four RCTs and 404 patients are included in the meta-analysis. Overall, compared with control group endoscopic sinus surgery, magnesium sulfate has remarkably positive impact on surgical field scores (MD = −1.76; 95% CI = −2.33 to −1.18; P < .00001), and intraoperative blood loss (MD = −89.09; 95% CI = −163.20 to −14.97; P = .02), but shows no markedly effect on surgery duration (MD = −7.08; 95% CI = −21.38 to 7.22; P = .33), fentanyl (MD = −0.64; 95% CI = −1.97 to 0.70; P = .35), and vecuronium (MD = −3.64; 95% CI = −10.99 to 3.70; P = .33). Conclusions: Magnesium sulfate exerts positive impact on surgical field and blood loss reduction for endoscopic sinus surgery.

Evaluation of the Efficacy of Magnesium Sulfate in Reducing Blood Loss in Functional Endoscopic Sinus Surgery: A Randomized Double-Blinded Controlled Trial

“…In our study, additional 0.5 mcg/kg fentanyl was given if the heart rate and systolic blood pressure increased more than 20%, was comparable in both groups, and was found to be statistically insignificant. Liu et al conducted a study in which there was no significant reduction in the requirement for fentanyl, which is similar to our study [12].…”

“…This finding is consistent with the study by Liu et al, who also compared the use of MgSO 4 with placebo in patients undergoing endoscopic sinus surgery. They concluded that MgSO 4 was associated with a significantly lower amount of intraoperative blood loss and improved the surgical field grading as compared to a placebo [12].…”

A Comprehensive Review of Magnesium Sulfate Infusion: Unveiling the Impact on Hemodynamic Stability During Laryngoscopy and Tracheal Intubation in Ear, Nose, and Throat Surgeries

“…Procedures with heightened hemodynamic challenges or those requiring prolonged airway management may warrant a more proactive approach to maintain stability, making MgSO 4 a strategic choice in the overall perioperative management of ENT surgeries. This patientcentric and procedure-specific approach enhances the precision and efficacy of MgSO 4 infusion in the ENT setting [32].…”