The Effect of Magnesium Deficiency on Neurological  Disorders: A Narrative Review Article

Xue, Wenwen; You, Jing; Su, Yingchao; Wang, Qinglu

doi:10.18502/ijph.v48i3.880

Cited by 15 publications

(13 citation statements)

References 56 publications

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“…The exact cause of its pathological changes is still not very clear, although genetic, aging, and oxidative stress have been suggested to be linked to it. It has been shown that the concentration of magnesium in the cortex, white matter, basal ganglia, and brainstem of the PD brain is low [ 385 , 386 ]. However, the association between circulating magnesium and PD is still ambiguous and controversial.…”

Section: Magnesium Deficiency and High Social Impact Diseasesmentioning

confidence: 99%

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

et al. 2021

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Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and in general the deficiency of this micronutrient induce changes in biochemical pathways that can increase the risk of illness and, in particular, chronic degenerative diseases. The assessment of magnesium status is consequently of great importance, however, its evaluation is difficult. The measurement of serum magnesium concentration is the most commonly used and readily available method for assessing magnesium status, even if serum levels have no reliable correlation with total body magnesium levels or concentrations in specific tissues. Therefore, this review offers an overview of recent insights into magnesium from multiple perspectives. Starting from a biochemical point of view, it aims at highlighting the risk due to insufficient uptake (frequently due to the low content of magnesium in the modern western diet), at suggesting strategies to reach the recommended dietary reference values, and at focusing on the importance of detecting physiological or pathological levels of magnesium in various body districts, in order to counteract the social impact of diseases linked to magnesium deficiency.

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Section: Magnesium Deficiency and High Social Impact Diseasesmentioning

confidence: 99%

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

et al. 2021

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“…The details of the mechanism are that Mg blocks the calcium channel of the n-methyl- d -aspartic acid receptor and inhibits the production of glutamatergic excitation signals [ 343 , 344 ]. Mg deficiency is associated with many nervous system diseases, such as cerebral vasospasm, Alzheimer's disease, stroke, and migraine [ 345 ]. In vivo experiments in horses have shown that oral or intravenous Mg might reduce the signs of trigeminal neuralgia [ 346 , 347 ].…”

Section: Perspectivesmentioning

confidence: 99%

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Xia

Yang

Zheng

et al. 2021

Bioactive Materials

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The oral and maxillofacial regions have complex anatomical structures and different tissue types, which have vital health and aesthetic functions. Biodegradable metals (BMs) is a promising bioactive materials to treat oral and maxillofacial diseases. This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications. Mg-based BMs and Zn-based BMs for bone fracture fixation systems, and guided bone regeneration (GBR) membranes, are discussed in detail. Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation. Fe-based BMs have a relatively low degradation rate and insoluble degradation products, which greatly limit their application and clinical translation. Furthermore, we proposed potential future research directions for BMs in the oral and maxillofacial regions, including 3D printed BM bone scaffolds, surface modification for BMs GBR membranes, and BMs containing hydrogels for cartilage regeneration, soft tissue regeneration, and nerve regeneration. Taken together, the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation.

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“…High extracellular Mg 2? switches the pathway to form soluble APP and CTFa, which is neurotrophic (Xue et al 2019;Gröber et al 2015;Kirkland et al 2018). Further, Mg 2?…”

Section: Neurodegenerative Diseases Parkinson's Diseasementioning

confidence: 99%

‘Magnesium’-the master cation-as a drug—possibilities and evidences

Mathew

Panonnummal

2021

Biometals

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Magnesium (Mg 2? ) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg 2? ) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn't get much attention in account with its functions, making it a ''Forgotten cation''. Like other cations, maintenance of the normal physiological level of Mg 2? is important. Its deficiency is associated with various diseases, which point out to the importance of Mg 2? as a drug. The roles of Mg 2? such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg 2? are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence. Keywords Magnesium Á Calcium antagonist Á Hypomagnesemia Á NMDA blocker Á Forgotten cation Á Vasodilator Abbreviations ACE Angiotensin converting enzyme AD Alzheimer's disease (AD) ALP Alkaline phosphatase ALT Aminotransferase AMPA a-Amino-3-hydroxy-5-methyl-4isoxazolepropionic acid APP Amyloid precursor protein AST Aspartate aminotransferase ATP Adenosine triphosphate BBB Blood brain barrier BMD Bone mineral density BMP2 Bone morphogenetic protein 2 BP Blood pressure cAMP Cyclic Adenosine mono phosphate CAD Coronary arytery diseases CFTR Cystic fibrosis transmembrane conductance regulator CGRP Calcitonin gene related peptide CHF Congestive heart Failure Claudin CLDN CNS Central nervous system CSD Cortical spreading depression CSF Cerebrospinal fluid CTF b C terminal fragment b CVD Cardiovascular diseases

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The Effect of Magnesium Deficiency on Neurological Disorders: A Narrative Review Article

Cited by 15 publications

References 56 publications

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

‘Magnesium’-the master cation-as a drug—possibilities and evidences

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