The effect of m-alkoxyphenol compounds on the Chromobacterium violaceum respiration metabolic rate

Synthesis, Antibacterial Activity and Quantum-Chemical Studies of Novel 2-Arylidenehydrazinyl-4-arylthiazole Analogues

“…24) Lipophilic character of a molecule is the most important factor for their antibacterial activity which helps to cross the cellular membrane or irreversibly damages the cellular membrane. 25) Figure 2 shows the molecular lipophilicity potential (MLP) map of inactive (2a) and active (2c, 2j) thiazole analogues, suggesting that the latter two compounds are more lipophilic than the former compound. In the present study, the log P of the most active compounds 2c (5.68) and 2j (5.03) are much higher than those of lower active compounds 2e (3.45), 2f (3.92), 2h (4.63), 2i (4.61) and inactive compounds 2a (3.96), 2b (4.40) and 2d (3.48).…”