The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial

Regenerative medicine in aesthetics

“…A recent split-face study of 19 women compared the efficacy of lyophilized PRP with saline injection. [35] A higher increase in dermal thickness was observed with saline solution, with no difference in collagen synthesis among the two arms. The synergistic effect of PRP with hyaluronic acid was reported by another large trial, and significant improvement in skin elasticity and facial appearance was noted with the combination as compared to either therapy alone.…”

Evidence-Based Efficacy of Platelet-Rich Plasma in Facial Rejuvenation

“…Despite the small group of patients included, the study conducted by da Siva et al, 7 is worth special attention. In a nonrandomized split-face controlled trial, the authors compared lyophilized PRP presenting 10 times the platelet baseline value and GFs, to saline.…”

“…Any described PRP clinical rejuvenation so far has been at best extremely modest 9 and available proof about clinical effectiveness of PRP therapy for facial rejuvenation is not very conclusive. On the contrary, regardless of the PRP preparation used, studies with reasonable level of evidence do not demonstrate any clinically significant effect to PRP injections 7,10 …”

“…4 Three very recently reported studies with high level of evidence are very informative and are worth reviewing carefully. 5,6,7 A randomized split-face clinical trial comparing a single PRP injection to saline in 27 patients with cheek rhytids of Glogau class II or greater was conducted by Alam et al 5 conducted. With blinding both participants and raters, a single PRP injection without activation was performed to 1 cheek with an equivalent volume of sterile normal saline injected to the contralateral cheek.…”

“…On the contrary, regardless of the PRP preparation used, studies with reasonable level of evidence do not demonstrate any clinically significant effect to PRP injections. 7,10…”