The effect of luminal ghrelin on pancreatic enzyme secretion in the rat

Nawrot-Porąbka, Katarzyna; Jaworek, Jolanta; Leja-Szpak, Anna; Szklarczyk, Joanna; Macko, Magdalena; Kot, Michalina; M, Mitis-Musioł; Konturek, Stanisław J.; Pawlik, Wiesław W.

doi:10.1016/j.regpep.2007.03.001

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…In rats, intraduodenal infusion of ghrelin was shown to dose dependently enhance basal and stimulated amylase secretion, an effect that was accompanied by an increase in plasma CCK concentration (138). This effect was attributed to an indirect action of ghrelin which was dependent on the stimulation of CCK release and activation of an enteropancreatic vago-vagal reflex (67,138). However, in other studies ghrelin significantly inhibited CCK-stimulated pancreatic exocrine secretion in vivo as well as in pancreatic lobule preparations but did not affect basal amylase release.…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 97%

“…Similarly, ghrelin's action on amylase secretion is unclear. In rats, intraduodenal infusion of ghrelin was shown to dose dependently enhance basal and stimulated amylase secretion, an effect that was accompanied by an increase in plasma CCK concentration (138). This effect was attributed to an indirect action of ghrelin which was dependent on the stimulation of CCK release and activation of an enteropancreatic vago-vagal reflex (67,138).…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 99%

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The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

101

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Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. The islet innervation and vascular anatomy have been more fully characterized and provide an appropriate background for our current understanding. The interrelationship between the endocrine and exocrine pancreas is mediated by islet-derived hormones such as insulin and somatostatin, other humoral factors including pancreastatin and ghrelin, and also neurotransmitters (nitric oxide, peptide YY, substance P, and galanin) released by the nerves innervating the pancreas. Although considerable progress has been achieved, further work is required to fully delineate the complex interplay of the numerous mechanisms involved. This review aims to provide a comprehensive update of the current literature available, bringing together data gleaned from studies addressing the actions of individual hormones, humoral factors, and neurotransmitters on the regulation of amylase secretion from the acinar cell. This comprehensive view of the islet-acinar axis of the pancreas while acknowledging the dominant role played by insulin and somatostatin on exocrine secretion sheds light on the influence of the various neuropeptides on amylase secretion.

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Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 97%

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 99%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

101

View full text Add to dashboard Cite

show abstract

“…CCK is produced and secreted by highly specialised enteroendocrine cells (I-cells) located in the duodenal and jejunal mucosa of the gut [2] and it is also expressed in the central and enteric nervous systems [3,4]. Basal CCK levels are typically in the low picomolar range and they increase approximately ten-fold following nutrient ingestion [5].…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic effects of dietary fatty acids on cholecystokinin expression, storage and secretion in enteroendocrine STC‐1 cells

Hand

Bruen

O’Halloran

et al. 2010

Molecular Nutrition Food Res

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Cholecystokinin (CCK) is a peptide hormone secreted from the I-cells of the intestine and it has important physiological actions related to appetite regulation and satiety. In this study we used STC-1 cells to investigate the effects of common dietary-derived fatty acids (FAs) on I-cell secretory function and metabolism. We extend earlier studies by measuring the acute and chronic effects of 11 FAs on CCK secretion, cellular CCK content, CCK mRNA levels, cellular DNA synthesis, cellular viability and cytotoxicity. FAs were selected in order to assess the importance of chain length, degree of saturation, and double bond position and conformation. The results demonstrate that secretory responses elicited by dietary FAs are highly selective. For example, altering the conformation of a double bond from cis to trans (i.e. oleic acid versus elaidic acid) completely abolishes CCK secretion. Lauric acid appears to adversely affect I-cell metabolism and arachidonic acid suppresses DNA synthesis. Our studies reveal for the first time that conjugated linoleic acid isoforms are particularly potent CCK secretagogues, which also boost intracellular stores of CCK. These actions of conjugated linoleic acid may explain satiating actions observed in dietary intervention studies.

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“…Increased CCK concentration in blood in our experiment may be connected with stimulating actions of apelin on neurohormonal mediators and neurotransmitters, which activates CCK secretion. It was also previously found that regulatory peptides including apelin (Wang et al, 2009), leptin (Sobhani et al, 2002), ghrelin (Kapica et al, 2006;Nawrot-Porąbka et al, 2007) and obestatin (Kapica et al, 2007) when secreted into the gastric lumen, may reach the intestinal lumen and stimulate CCK secretion (Zabielski et al, 1998). In studies it was observed that apelin stimulated CCK secretion from a murine enteroendocrine cell line by mitogen-activated protein kinase (MAPK) pathway.…”

Section: Discussionmentioning

confidence: 93%