The Effect Of &lt;i&gt;Tetracera potatoria&lt;/i&gt; And Its Constituent Betulinic Acid On Gastric Acid Secretion And Experimentally- Induced Gastric Ulceration

Adesanwo, JK; Ekundayo, Olusegun; Oluwole, F. S.; Olajide, OA; Berge, Ajj van den; Findlay, JA

doi:10.4314/njps.v18i1.32613

Cited by 5 publications

(6 citation statements)

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“…The structure of the compound was elucidated by Nuclear Magnetic Resonance (NMR) and Infra-red (IR) spectroscopy, including attached proton test spectrum of its acetylated product and comparison with authentic samples was done. The NMR data is in agreement with those reported by earlier workers (Andrenick et al, 1995;Adesanwo et al, 2003).…”

Section: Isolation Of Betulinic Acidsupporting

confidence: 93%

“…T. potatoria is used extensively in ethnomedicinal practice in West Africa for treatment of diseases of inflammatory origin. The sap and the powdered leaf are used for treatment of toothache and cough, and it is also administered to lactating mothers as a galactogogue (Adesanwo et al, 2003). The aqueous extract of the root is used as a remedy for intestinal disorders, while the stems are macerated in its own sap and administered for treatment of leprosy and stomach complaint in Senegal (Burkill, 1985).…”

Section: Introductionmentioning

confidence: 99%

“…The aqueous extract of the root is used as a remedy for intestinal disorders, while the stems are macerated in its own sap and administered for treatment of leprosy and stomach complaint in Senegal (Burkill, 1985). Adesanwo et al (2003) reported that Tetracera potatoria and its constituent betulinic acid reduced gastric acid secretion and increased rate of healing of experimentally-induced gastric ulceration. This research is a further study on the pharmacological activity of betulinic acid, a bioactive principle isolated from T. potatoria.…”

Section: Introductionmentioning

confidence: 99%

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Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from <i>Tetracera Potatoria</i>.

Oyebanji¹,

Saba²,

Oridupa³

2013

Afr. J. Trad. Compl. Alt. Med.

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Background: The anti-inflammatory and anti-nociceptive activity of betulinic acid (BA) was investigated in this study. The triterpene was isolated from the ethyl acetate extract of Tetracera potatoria and its structure was verified by IR and NMR spectroscopy. The bioactivity of this compound was assessed using carrageenan-induced paw oedema in rats and carrageenan-induced pulmonary oedema in mice for the antiinflammatory activity, while acetic acid-induced writhing test in mice and zymosan-induced fever in rats were used for analgesic test. Materials and Methods: Rats and mice were randomly divided into groups of five animals. For each experiment, betulinic acid at 10, 20 or 40mg/kg b.w was administered intraperitoneally to the first three groups respectively. The fourth group was administered with indomethacin (10mg/kg) or acetylsalicylic acid (150mg/kg), while the fifth group was administered with distilled water (10ml/kg). Data obtained were expressed as mean±S.E.M and significant differences were determined at p<0.05. Results: BA significantly reduced carrageenan-induced paw oedema by 11.0%, 45.7%, 68.6% or pulmonary oedema by 25.6, 29.2 and 45.13% dose dependently. 40 mg/kg of BA inhibited paw oedema by 68.6% comparably to acetylsalicylic acid (71.4%) or indomethacin (51.33%) respectively. Abdominal writhing was also significantly (p<0.05) reduced to 17.20 writhes by BA (40mg/kg) comparable to Indomethacin (16.3writhes). Fever was inhibited by BA most significantly by 3hours post-injection of zymosan (1.00, 1.45, 0.00 0 C) and this inhibitory effect was higher than that observed for acetylsalicylic acid (0.30 0 C). Conclusion: Betulinic acid derived from Tetracera potatoria exhibited potent anti-inflammatory, analgesic or antipyrexic activity which is comparable to indomethacin or acetylsalicyclic acid.

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Section: Isolation Of Betulinic Acidsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from <i>Tetracera Potatoria</i>.

Oyebanji¹,

Saba²,

Oridupa³

2013

Afr. J. Trad. Compl. Alt. Med.

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“…One hour after administrations of 100, 200 and 400 mg/kg/bw of H. indicum and 50 mg/kg/bw of Ranitidine; 80 mg/kg/bw of Indomethacin was administered orally to rats of Groups III -VI (Adesanwo et al, 2003;Raji et. al., 2003).…”

Section: Gastro-protective Activity Of H Indicummentioning

confidence: 99%

“…After four hours, the animals were sacrificed by cervical dislocation and the stomach of each rat was removed. The stomach was opened along the lesser curvature and washed with normal saline to remove any debris (Adesanwo et al, 2003;Raji et. al., 2003).…”

Section: Gastro-protective Activity Of H Indicummentioning

confidence: 99%

Gastroprotective Activities of the n-Hexane Fraction of Heliotropium indicum on Gastric Ulceration

Ayoola¹,

Akinlolu²,

Adeboga³

et al. 2016

Nig J Bas App Sci

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Heliotropium indicum has been established to possess gastroprotective properties. We evaluated the gastroprotective properties of the non-polar (n-hexane) fraction of H. indicum to establish its anti-ulcer activities. Rats of Groups I and II received physiological saline and 80 mg/kg/body weight (bw) of Indomethacin respectively. Rats of Groups III -VI received orally 100, 200 and 400 mg/kg/bw of the n -hexane fraction of methanolic extracts of dried leaves of H. indicum and 50 mg/kg/bw of Ranitidine respectively before the induction of gastric ulceration. One hour after administration of extract doses and Ranitidine, 80 mg/kg/bw of Indomethacin (an ulcerogen) was administered orally to rats of Groups III -VI. Morphological analyses show that administrations of 100, 200 and 400 mg/kg/bw of extract and Ranitidine resulted in percentage ulcer reductions of 45%, 50%, 75% and 95% respectively. Histological analyses of the stomach in rats of Groups II and III show erosion of mucus-secreting cells, parietal cells, gastric pit and glands. Erosion of few mucus-secreting cells, gastric pit and parietal cells were observed in rats of Group IV. Normal cytoarchitectures of the mucosa layer were observed in rats of Groups I, V and VI. Our findings show that the n-hexane fraction of H. indicum possessed gastroprotective properties.

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Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

Ignatius

Narayanan

Subramanian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.

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The Effect Of <i>Tetracera potatoria</i> And Its Constituent Betulinic Acid On Gastric Acid Secretion And Experimentally- Induced Gastric Ulceration

Cited by 5 publications

References 0 publications

Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from <i>Tetracera Potatoria</i>.

Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from <i>Tetracera Potatoria</i>.

Gastroprotective Activities of the n-Hexane Fraction of Heliotropium indicum on Gastric Ulceration

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

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