The Effect of &lt;i&gt;Tempe Gembus&lt;/i&gt; on High-Sensitivity C-Reactive Protein and Adiponectine Levels in Rats with Metabolic Syndrome

Sulistyaningsih, Ikawati; Afifah, Diana Nur; Juniarto, Achmad Zulfa; Anjani, Gemala; Rustanti, Ninik

doi:10.3177/jnsv.66.s51

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…The giving of high fat and high carbohydrate food on rats were able to induce the same condition of metabolic 40 High fat diet derived from lard and quail egg yolks were able to increase body weight, level of plasma triglyceride, concentration of free fatty acid, and concentration of plasma insulin, also decreased the concentration of plasma adiponectin. It was due to the high content of trans fatty acid from lard and high cholesterol from the egg yolks.…”

Section: Induction Period -Intervention Periodmentioning

confidence: 91%

“…22 Besides, sucrose giving with high concentration in 2 weeks could turn up the phenotype resistance insulin and hypertriglyceridemia on Sprague Dawley and Wistar rats. 40 Tempeh gembus giving for 28 days inhibit the weight gain on treatment group. Tempeh gembus with doses of 7.5 g had the lowest of mean body weight and mean weight gain than other groups.…”

Section: Induction Period -Intervention Periodmentioning

confidence: 94%

“…24 Research in Bali indicated the prevalence of metabolic syndrome of 18.2% among 1,840 subjects. 40 Another study in Jakarta reported that grossly obese children (5~9 years old) of whom 52% had dyslipidemia and 35.6% in insulin resistance. 36 One of the causal factors of metabolic syndrome is frequent and excessive consumption of foods and beverages that contained high carbohydrates (especially sucrose and fructose) and high fats (especially saturated fatty acid and trans fatty acid).…”

Section: Introductionmentioning

confidence: 98%

“…36 One of the causal factors of metabolic syndrome is frequent and excessive consumption of foods and beverages that contained high carbohydrates (especially sucrose and fructose) and high fats (especially saturated fatty acid and trans fatty acid). 40 Metabolic syndrome and oxidative stress are interlinked and are marked by high levels of malondialdehyde (MDA) and low levels of superoxide dismutase (SOD) enzyme activity. The high levels of MDA are due to Reactive Oxygen Species (ROS) acting on the lipid cell membranes by peroxidation of membrane fatty acids.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Tempeh gembus on Malondialdehyde and Superoxide Dismutase Enzyme Levels in Rats with Diet-Induced Metabolic Syndrome

Rachmawati

Afifah

Rustanti

et al. 2021

J. Biomed. Transl. Res.

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Background: High level of malondialdehyde (MDA) and low level of superoxide dismutase (SOD) are markers of oxidative stress and indicate enhance metabolic syndrome. Tempeh gembus is a food that has antioxidant properties which can decreased MDA concentration and increased SOD enzyme activity.Objective: The aim of this research was to determine the effect of Tempeh gembus on plasma MDA and serum SOD enzyme levels in metabolic syndrome rats.Methods: A post-test only experimental design was used in which 25 Sprague Dawley rats were divided into 5 equal groups of 2 control groups (K- and K+) and 3 treatment groups (P1, P2, P3). Metabolic syndrome was induced in the K+ control and the 3 treatment groups. Tempeh gembus were given for 4 weeks with the doses of 2.5g (P1), 5g (P2), and 7.5g (P3). Plasma MDA levels were measured by the Thiobarbituric Acid Reactive Substance (TBARS) method and serum SOD enzyme levels were measured by the Enzyme Linked Immunosorbent Assay (ELISA) method. The statistical analysis used One Way Anova test.Results: Tempeh gembus significantly decreased plasma MDA levels of metabolic syndrome rats (P=0.000) but had no significant effect on serum SOD enzyme levels in each treatment group (P=0.449).Conclusion: The dose of 7.5g Tempeh gembus was the most effective dose in reducing the plasma MDA level. Tempeh gembus in the 3 treatment doses significantly decreased plasma MDA levels but had no significant effect on serum SOD enzyme levels.

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Section: Induction Period -Intervention Periodmentioning

confidence: 91%

Section: Induction Period -Intervention Periodmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The Effect of Tempeh gembus on Malondialdehyde and Superoxide Dismutase Enzyme Levels in Rats with Diet-Induced Metabolic Syndrome

Rachmawati

Afifah

Rustanti

et al. 2021

J. Biomed. Transl. Res.

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SARS-CoV-2 and microbiome

Sankova

Николенко

Sankov

et al. 2023

Autoimmunity, COVID-19, Post-Covid19 Syndrome and COVID-19 Vaccination

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Functional Food Innovation for the Treatment of Metabolic Syndrome

Bintanah

Ulvie

Kusuma

et al. 2023

Food Sustainability, Environmental Awareness, and Adaptation and Mitigation Strategies for Developing Countries

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Metabolic syndrome (MetS) is a metabolic disorder characterized by central obesity, insulin resistance, hypertension, and hyperlipidemia. MetS is associated with an increase in reactive oxygen species (ROS), triggered by oxidative stress. Oxidative stress occurs when the number of free radicals in the body exceeds its ability to neutralize them, causing cells, tissues, or organs damage, and triggering type 2 diabetes mellitus (DM) and coronary heart disease. One of the ways to manage of MetS is through functional food. Various studies have shown that functional foods contain bioactive components such as dietary fibers (beta-glucans, pectin, inulin), phytosterols, oleic acid, polyunsaturated fatty acids, antioxidant vitamins, phytochemicals such as flavonoids, and bioactive peptides. In addition, functional food processing uses state-of-the-art technology that generates heat through internal transmission energy and does not use high-temperature technology. This minimizes the deterioration of sensory characteristics, nutrients, and functional foods.

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The Effect of <i>Tempe Gembus</i> on High-Sensitivity C-Reactive Protein and Adiponectine Levels in Rats with Metabolic Syndrome

Cited by 4 publications

References 35 publications

The Effect of Tempeh gembus on Malondialdehyde and Superoxide Dismutase Enzyme Levels in Rats with Diet-Induced Metabolic Syndrome

The Effect of Tempeh gembus on Malondialdehyde and Superoxide Dismutase Enzyme Levels in Rats with Diet-Induced Metabolic Syndrome

SARS-CoV-2 and microbiome

Functional Food Innovation for the Treatment of Metabolic Syndrome

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