The Effect of &lt;b&gt;&lt;i&gt;Allium cepa&lt;/i&gt;&lt;/b&gt; Extract on Lung Oxidant, Antioxidant, and Immunological Biomarkers in Ovalbumin-Sensitized Rats

Marefati, Narges; Eftekhar, Naeima; Kaveh, Mahsa; Boskabadi, Javad; Beheshti, Farimah; Boskabady, Mohammad Hossein

doi:10.1159/000487885

Cited by 42 publications

(35 citation statements)

References 29 publications

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“…Previous studies have reported that oxidative stress markers such as NO 2 , NO 3 , and MDA were amplified, whereas SOD, catalase, IFN‐γ were found declined in the asthmatic animals when compared with normal control group. In contrast, the total white blood corpuscles (WBC count), NO 2 and NO 3 were found significantly reduced in the dexamethasone and plant extract treated asthmatic groups (Marefati et al, ; Shakeri, Soukhtanloo, & Boskabady, ). Ceylan et al () reported that MDA levels were significantly higher and glutathione levels were lower in the blood plasma of asthmatic patients.…”

Section: Discussionmentioning

confidence: 99%

“…Asthma is a chronic inflammatory disease that weakens the airways in lungs and hinders breathing. Vigorous inductions of inflammatory cells, excessive mucus generation, airway narrowing, and bronchial hyper reactivity are the major mediators of asthma (Marefati et al, ). Similar to autoimmune diseases, asthmatic response also involves a wide range of immune cells including mast cells, eosinophils, neutrophils, airway epithelial cells, smooth muscle cells, and T‐lymphocytes (Gao, Ying, & Dai, ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Zhang

Wang

et al. 2018

Drug Development Research

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Asthma is termed as the induction of chronic inflammation in the airway lumen of lungs due to accumulation of inflammatory cells which affects normal breathing process. Prolonged accumulation of inflammatory cells leads to oxidative stress and suppression of antioxidant activities. Therefore, in our present investigation, a potential phenolic compound, Syringic acid was tested for the suppression of inflammatory markers toward an antiasthmatic activity in ovalbumin (OVA)‐induced asthmatic mice model. As a result, the Syringic acid treatment was found to suppress the inflammatory cells; eosinophil, neutrophil, macrophage, lymphocyte, and other inflammatory markers including IL‐4, IL‐5, IL‐13, and TNF‐α in the BALF of OVA‐induced asthmatic mice. Similarly, IgE levels were significantly reduced in the blood serum of Syringic acid treated mice groups. In this context, the IFN‐γ levels were found enhanced in the BALF of Syringic acid treated asthmatic mice groups, expressing an anti‐inflammatory response. Enzymatic and nonenzymatic antioxidants such as SOD, CAT, and GSH levels were found high in the Syringic acid treatment than the asthmatic control group, which depicts the antioxidant response of Syringic acid on asthmatic groups. Intriguingly, the ROS, NO2, NO3, and MDA levels were inhibited in the BALF of Syringic acid treated mice groups. The airway hyper‐reactivity (AHR) was comparatively normal in the Syringic acid treatment as it was severe in the case of asthmatic control group. Consequently, the effect of Syringic acid is prominent in the treatment of asthma by controlling the accumulation of inflammatory cells, other inflammatory markers along with enhancement of antioxidant markers, suppression of ROS and controlling airway hyperreactivity. Hence, Syringic acid may be recommended for clinical trials in the treatment of asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Zhang

Wang

et al. 2018

Drug Development Research

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“…Allium cepa L. (Family Amaryllidaceae) is one of the most commonly consumed vegetables and has also been used for medicinal purposes for numerous ailments such as ulcer wounds, scars, dysentery, inflammation, hypertension and also in respiratory conditions such as cough, asthma, and bronchitis ( Lanzotti, 2006 ; Upadhyay, 2016 ; Zeng et al, 2017 ). Onion bulb extract (OBE) has also been shown to effectively reduce airway inflammation, IL4, and IgE levels and induces oxidation in animal models of asthma ( Oliveira et al, 2015 ; Marefati et al, 2018 ). Thiosulfinates (TS) and cepaenes (CS), isolated from onions and/or synthesized, were also shown to have dose-dependent inhibitory effects on both cyclooxygenase and 5-lipoxygenase activity ( Dorsch et al, 1990 ; Wagner et al, 1990 ) and inhibit in vitro chemotaxis of human granulocytes induced by formyl-methionine-leucine-phenylalanine (WKYMvm) ( Dorsch et al, 1990 ).…”

Section: Introductionmentioning

confidence: 99%

Onion Bulb Extract Downregulates EGFR/ERK1/2/AKT Signaling Pathway and Synergizes With Steroids to Inhibit Allergic Inflammation

et al. 2020

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The treatment of allergic diseases, such as asthma, with both conventional and novel therapies presents a challenge both in terms of optimal effect and cost. On the other hand, traditional therapies utilizing natural products such as onion have been in use for centuries with demonstrated efficacy and safety but without much knowledge of their mechanims of action. In this study, we investigated if the anti-inflammatory effects of onion bulb extract (OBE) are mediated via the modulation of the EGFR/ERK1/2/AKT signaling pathway, and whether OBE can synergise with steroids to produce greater anti-inflammatory actions. Treatment with OBE inhibited the house dust mite (HDM)-induced increased phosphorylation of EGFR, ERK1/2 and AKT which resulted in the inhibition of HDM-induced increase in airway cellular influx, perivascular and peribronchial inflammation, goblet cell hyper/metaplasia, and also inhibited ex vivo eosinophil chemotaxis. Moreover, treatment with a combination of a low dose OBE and low dose dexamethasone resulted in a significant inhibition of the HDM-induced cellular influx, perivascular and peribronchial inflammation, goblet cell hyper/metaplasia, and increased the pERK1/2 levels, whereas neither treatment, when given alone, had any discernible effects. This study therefore shows that inhibition of the EGFR/ERK1/2/AKT-dependent signaling pathway is one of the key mechanisms by which OBE can mediate its anti-inflammatory effects in diseases such as asthma. Importantly, this study also demonstrates that combining OBE with steroids results in significantly enhanced anti-inflammatory effects. This action may have important potential implications for future asthma therapy.

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“…Inflammatory cells elevated in BAL fluid are also source of leukotrienes that are formed by the breakdown of a membrane constituent, arachidonic acid, via the 5-lipoxygenase enzyme pathway. Leukotrienes may a play an important role in attracting neutrophils and eosinophils into airways, and produce P a g e / S a y f a 64 bronchoconstriction, mucus secretion, microvascular leakage, airway edema, and neuronal interactions [14,17,[26][27][28]. Therefore, the reduction of leukocyte infiltration may be a mechanism for the beneficial effect of TQ.…”

Section: Discussionmentioning

confidence: 99%

Thymoquinone exhibits anti-inflammatory, antioxidant, and immunomodulatory effects on allergic airway inflammation

Parlar

Arslan

2019

Archives of Clinical and Experimental Medicine

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Aim: Asthma is an allergic disease causing mucus secretion, release various pro-inflammatory mediators such as tumor necrosis factor-α (TNF-α) and interleukins. The aim of this study was to evaluate the effect of thymoquinone (TQ) on allergic airway inflammation in rats. Methods: Allergic airway inflammation induced by ovalbumin (OVA) challenge in sensitized-rats and effect of TQ were studied. Inflammatory cells, interleukin (IL)-6 and TNF-α in bronchoalveolar lavage (BAL) fluid, and lipid peroxidation (LPO) in lung tissue were measured. Microvascular leakage was detected by Evans blue dye leakage in airway tissues. Results: Tidal volume was significantly lower in OVA group (1.4± 0.07 ml) than control group (1.9±0.04 ml) (p = 0.002), while breathing frequency was significantly higher in OVA group (135.3±12.9 min-1) than control group (p=0.017). In terms of tidal volume, statistical significance between TQ30 and OVA groups was found (1.8±0.07 ml) (p=0.008), while in terms of breathing frequency, no significance was found between both of them (126.7±7.3). Total white blood cell count was significantly higher in OVA group (1,376.8±136.4 x103/ml) than control group (545.0±106.7 x103/ml) (p<0.001). Statistical significance was found in TQ10 (824.7±4.5 x103/ml) group when compared OVA group (p=0.036), while statistical significance was not found in TQ1 group (1,282.2±137.7 x103/ml). When compared OVA group (60.3±4.9 pg/ml) with control group in terms of the TNF-α level, statistical significance was found (36.7± 4.7 pg/ml) (p=0.011). The Evans blue dye level was significantly higher in OVA group (31.8±3.6 ng/mg of tissue) than control (12.5±1.1 ng/mg of tissue) group (p<0.001), and TQ10 group (16.3±6.7 ng/mg of tissue) (p=0.002), and TQ30 (13.5±1.0 ng/mg of tissue) group (p<0.001). Conclusion: These findings reveal that TQ could be beneficial in asthma pathophysiology due to its immunomodulatory, anti-inflammatory, and antioxidant effects.

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The Effect of <b><i>Allium cepa</i></b> Extract on Lung Oxidant, Antioxidant, and Immunological Biomarkers in Ovalbumin-Sensitized Rats

Cited by 42 publications

References 29 publications

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Onion Bulb Extract Downregulates EGFR/ERK1/2/AKT Signaling Pathway and Synergizes With Steroids to Inhibit Allergic Inflammation

Thymoquinone exhibits anti-inflammatory, antioxidant, and immunomodulatory effects on allergic airway inflammation

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