Despite its effectiveness in eradicating cancer cells,
current
tumor radiotherapy often causes irreversible damage to the surrounding
healthy tissues. To address this issue and enhance therapeutic outcomes,
we developed a multifunctional injectable hydrogel that integrates
electromagnetic shielding and magnetothermal effects. This innovation
aims to improve the efficacy of brachytherapy while protecting adjacent
normal tissues. Recognizing the limitations of existing hydrogel materials
in terms of stretchability, durability, and single functionality,
we engineered a composite hydrogel by self-assembling nickel nanoparticles
on the surface of liquid metal particles and embedding them into an
injectable hydrogel matrix. The resulting composite material demonstrates
superior electromagnetic interference shielding performance (74.89
dB) and a rapid magnetothermal heating rate (10.9 °C/min), significantly
enhancing its in vivo applicability. The experimental results confirm
that this innovative nanocomposite hydrogel effectively attenuates
electromagnetic waves during brachytherapy, thereby protecting normal
tissues surrounding the tumor and enhancing radiotherapy efficacy
through magnetothermal therapy. This study advances the safety and
effectiveness of cancer treatments and provides new insights into
the development of multifunctional biomedical materials, promoting
the innovative application of nanotechnology in the medical field.