The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period

Łukomska, Agnieszka; Baranowska-Bosiacka, Irena; Budkowska, Marta; Pilutin, Anna; Tarnowski, Maciej; Dec, Karolina; Dołęgowska, Barbara; Metryka, Emilia; Chlubek, Dariusz; Gutowska, Izabela

doi:10.1016/j.chemosphere.2016.09.067

Cited by 12 publications

(10 citation statements)

References 53 publications

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“…However, we observed the hepatic mRNA levels of some genes such as cat, gpx did not change in a dose‐dependent manner after Pb exposure which might be result from the very low doses of Pb (0.03, 0.1 mg/L). As we mentioned before, the doses of Pb in this study were within the safety threshold of blood Pb for adults . In addition, the two concentrations we set were similar, which might be one of the reasons.…”

Section: Discussionmentioning

confidence: 74%

“…One group, serving as a control, drank Pb‐free water while the other two groups were treated with 0.03 or 0.1 mg/L Pb acetate trihydrate (Pb[CH 3 CO 2 ] 2 ·3H 2 O) supplied in the drinking water for 15 weeks. The concentrations of Pb were within the safety threshold (10 μg/dl) of blood Pb for adults . During the exposure, water and food were available ad libitum.…”

Section: Methodsmentioning

confidence: 94%

“…Public health concern over environmental heavy metals has increased in recent years . Lead (Pb) is a heavy metal that is highly toxic to humans and animals and is a persistent contaminant in environmental water, soil, and dust, and can also be present in manufactured products .…”

Section: Introductionmentioning

confidence: 99%

“…According to the Centers for Disease Control and Prevention (CDC), the safety threshold for blood Pb is currently 10 mg/dL for adults. However, it has been corrected to 5 mg/dL for children and pregnant women (CDC, 2012), as abundant evidence indicates Pb toxicity even below 10 mg/dL, especially in the developing brain . Given the widespread presence of environmental Pb contamination, there is great concern over the possible ecotoxicological impacts on various organisms.…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies, continuous exposure to Pb is a risk factor in nephrotoxicity and reproductive, behavioral dysfunctions, and even changed the gut microbiota . Considered the main detoxification organ, the liver is responsible for the absorption, degradation, and metabolism of exogenous chemicals including heavy metals.…”

Section: Introductionmentioning

confidence: 99%

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Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Luo

Shen

Zhou

et al. 2019

Environmental Toxicology

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Lead (Pb), a non-essential heavy metal, is a major global environmental contaminant with serious toxicological consequences. In the present study, the effects on hepatotoxicity of mice with chronic exposure to low doses of Pb were evaluated. While oral exposure to 0.03 or 0.1 mg/L Pb for 15 weeks in male adult mice had no significant effect on body weights, Pb exposure resulted in liver histopathological effects and increase of hepatic activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). In addition, hepatic reactive oxygen species (ROS) and malondialdehyde (MDA) significantly accumulated after treatment. Conversely, glutathione (GSH) decreased significantly in both 0.03 and 0.1 mg/L Pb-treated groups. Moreover, the hepatic activities of superoxide dismutase 1 (SOD) and catalase (CAT) increased significantly following treatment with 0.1 mg/L Pb for 15 weeks, concomitant with increases in transcriptions of hepatic Sod, Cat, and Gpx. Furthermore, transcriptions of hepatic metallothionein (MT), zinc transporter 5 (Znt5) and copper transporter 1 (Ctr1), and subsequent protein levels were also increased in liver of mice when exposed to 0.1 mg/L Pb for 15 weeks. In addition, the transcriptome data showed that Pb has substantial influence on several pathways, including PPAR signaling pathways, AMPK signaling pathways, fatty acid metabolism, and drug metabolism. Our data suggested that chronic Pb exposure could induce hepatotoxicity at the physiological, biochemical, and transcriptomic levels in mice. K E Y W O R D Shepatotoxicity, oxidative stress, gene expression, Pb

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Section: Discussionmentioning

confidence: 74%

Section: Methodsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Luo

Shen

Zhou

et al. 2019

Environmental Toxicology

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Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

et al. 2019

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Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence suggests fatty liver to have a positive correlation with serum lead (Pb2+) levels. However, an exact mechanism of Pb2+‐induced fatty liver progression is still unknown. Here, we show that exposure to Pb2+ regulates ChREBP‐dependent hepatic lipogenesis. Presence of Pb2+ ions within the hepatocytes reduces transcript and protein levels of sorcin, a cytosolic adaptor partner of ChREBP. Adenovirus‐mediated overexpression of sorcin in Pb2+ exposed hepatocytes and an in vivo mouse model ameliorates liver steatosis and hepatotoxicity. Hereby, we present Pb2+ exposure to be a lethal disruptor of lipid metabolism in hepatocytes and highlight sorcin as a novel therapeutic target against Pb2+‐induced hepatic dyslipidemia.

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Biochemical, histopathological and untargeted metabolomic analyses reveal hepatotoxic mechanism of acetamiprid to Xenopus laevis

Jiao

Yuan

Wang

et al. 2023

Environmental Pollution

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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period

Cited by 12 publications

References 53 publications

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

Biochemical, histopathological and untargeted metabolomic analyses reveal hepatotoxic mechanism of acetamiprid to Xenopus laevis

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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period

Cited by 12 publications

References 53 publications

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

Biochemical, histopathological and untargeted metabolomic analyses reveal hepatotoxic mechanism of acetamiprid to Xenopus laevis

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Chronic exposure to Pb²⁺ perturbs ChREBP transactivation and coerces hepatic dyslipidemia