The Effect of Low-Intensity Transcranial Ultrasound Stimulation on Neural Oscillation and Hemodynamics in the Mouse Visual Cortex Depends on Anesthesia Level and Ultrasound Intensity

Yuan, Yi; Zhang, Kaiqing; Zhang, Yiyao; Yan, Jiaqing; Wang, Zhijie; Wang, Xingrang; Liu, Mengyang; Li, Xiaoli

doi:10.1109/tbme.2021.3050797

Cited by 15 publications

(11 citation statements)

References 40 publications

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“…We found that ultrasound prevention and therapy did not reduce the CBF velocity in migraine rats. In previous research, there were significant changes of blood flow velocity following ultrasound stimulation, and it returned to baseline levels after 10 s of ultrasound stimulation [44]- [47] under different ultrasound parameters (Yoo et al [44], FF: 690 kHz, I sppa : (3.3, 6.4, 9.5, and 12.6 W/cm 2 ), PRFs: (10, 20, 100, and 1 kHz), SDs (0.5, 1, 1.5, and 2 s); Kim et al [45], FF: 425 kHz, PRFs (375, 750, 1.5 kHz), N cycles: (80, 40, and 20), I sppa : 1.84W/cm 2 ; Yuan et al [46], FF: 500 kHz, I sppa : 1.1 W/cm 2 , SD: 400 ms; Yuan et al [47], FF: 500 kHz, I sppa : 10.1W/cm 2 , PRF:1kHz, SD: 400ms). We hypothesized that blood flow velocity returned to the baseline level due to the long delay after stimulation.…”

Section: Discussionmentioning

confidence: 86%

“…At the mesoscopic level, previous studies have demonstrated that TUS can modulate neural information encoding, such as the spike rate and amplitude, power spectrum, and low-frequency or high-frequency phase amplitude coupling intensity of local field potential, in the cortex/hippocampus/thalamus of mice [39]- [43]. It can also alter cerebral hemodynamics and cerebral blood oxygen metabolism, such as increasing cerebral blood flow (CBF) speed and enhancing the intensity of neurovascular coupling between electrophysiology and brain blood oxygen [44]- [47]. At the microscopic level, researchers have demonstrated that TUS can modulate protein expression in brain tissue, such as by increasing the levels of brain-derived neurotrophic factor, glial cell-derived neurotrophic factor, and vascular endothelial growth factor and by reducing the levels of acetylcholine and Aβ [48]- [50].…”

Section: Introductionmentioning

confidence: 99%

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Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Yao

Chen

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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This study sought to systematically evaluate the prophylactic and therapeutic effects of low-intensity transcranial ultrasound stimulation on migraine in rats. We used video recordings to assess the head scratching behavior and laser speckle contrast imaging to record the changes in cerebral blood flow velocity of freely moving rats in a healthy group, migraine group, migraine group with ultrasound prevention, and migraine group with ultrasound therapy. Results demonstrated that (1) head scratching during migraine attacks in rats was accompanied by an increase in cerebral blood flow; (2) both ultrasound prevention and therapy significantly reduced the number of head scratches but did not reduce the cerebral blood flow velocity; and (3) the number of head scratches in the ultrasound stimulation groups was not affected by the auditory effect. These results reveal that low-intensity ultrasound has the potential to be used clinically in the prevention and therapeutic treatment of migraine.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Yao

Chen

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…If the ischemic penumbra is rescued in time, it can effectively prevent stroke progression; further, the successful rescue of ischemic penumbra is also conducive to the recovery of the nervous system and physical function in the future. TUS has been proved to be beneficial for the improvement of cerebral blood circulation after acute ischemic stroke, and within a certain range, cerebral blood flow also shows a gradually increasing trend with the increase of stimulation intensity and duration (Yuan et al, 2020(Yuan et al, , 2021Liu et al, 2021b). However, with an improvement in cerebral blood flow, the risk of rebleeding also increases.…”

Section: Rapid Restoration Of Cerebral Blood Supply and Improvement O...mentioning

confidence: 99%

The Updated Role of Transcranial Ultrasound Neuromodulation in Ischemic Stroke: From Clinical and Basic Research

Zhu¹,

Meng²,

Jiang³

et al. 2022

Front. Cell. Neurosci.

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Ischemic stroke is a common cause of death and disability worldwide, which leads to serious neurological and physical dysfunction and results in heavy economic and social burdens. For now, timely and effective dissolution of thrombus, and ultimately improvement in the recovery of neurological functions, is the treatment strategy focus. Recently, many studies have reported that transcranial ultrasound stimulation (TUS), as a non-invasive method, can dissolve thrombus, improve cerebral blood circulation, and exert a neuroprotective effect post-stroke. TUS can promote functional recovery and improve rehabilitation efficacy among patients with ischemic stroke. This mini-review summarizes the potential mechanism and limitation of TUS in stroke aims to provide a new strategy for the future treatment of patients with ischemic stroke.

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“…Non-invasive brain stimulation technologies have gradually played an important role in the researches of neuroscience and neurological diseases in recent decades. Low-intensity focused ultrasound stimulation (LIFUS), as an emerging non-invasive neuromodulation, has been rapidly developed with the advantage of excellent targeting, penetration depth, and spatial resolution ( Yuan et al, 2021 ). Among previous animal reports, LIFUS has been proved to be useful in treating various neurological and psychiatric diseases such as ischemic brain injury ( Guo et al, 2015 ; Li et al, 2017 ), depression ( Zhang et al, 2019 , 2021 ), and dementia ( Huang et al, 2017 ; Eguchi et al, 2018 ; Bobola et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment

Wang

Wang²,

Ren³

et al. 2022

Front. Aging Neurosci.

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Working memory impairment is one of the remarkable cognitive dysfunctions induced by vascular dementia (VD), and it is necessary to explore an effective treatment. Recently, low-intensity focused ultrasound stimulation (LIFUS) has been found notable neuroprotective effects on some neurological diseases, including VD. However, whether it could ameliorate VD-induced working memory impairment was still not been clarified. The purpose of this study was to address this issue and the underlying mechanism. We established VD rat model using the bilateral common carotid artery occlusion (BCCAO) and applied the LIFUS (center frequency = 0.5 MHz; Ispta = 500 mW/cm2, 10 mins/day) to bilateral medial prefrontal cortex (mPFC) for 2 weeks since 2 weeks after the surgery. The main results showed that the LIFUS could significantly improve the performance of VD rats in the specific working memory tasks (delayed nonmatch-to-sample task and step-down task), which might be associated with the improved synaptic function. We also found the improvement in the cerebral blood flow (CBF) and reduced neuroinflammation in mPFC after LIFUS treatment indicated by the inhibition of Toll-like receptor (TLR4)/nuclear factor kappa B (NF-κB) pathway and the decrease of proinflammatory cytokines. The amelioration of CBF and neuroinflammation may promote the living environment of the neurons in VD which then contribute to the survival of neurons and the improvement in synaptic function. Taken together, our findings indicate that LIFUS targeted mPFC can effectively ameliorate reward-based spatial working memory and fear working memory dysfunctions induced by VD via restoring the living environment, survivability, and synaptic functions of the neurons in mPFC of VD rats. This study adds to the evidence that LIFUS could become a promising and non-invasive treatment strategy for the clinical treatment of central nervous system diseases related to cognitive impairments in the future.

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The Effect of Low-Intensity Transcranial Ultrasound Stimulation on Neural Oscillation and Hemodynamics in the Mouse Visual Cortex Depends on Anesthesia Level and Ultrasound Intensity

Cited by 15 publications

References 40 publications

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

The Updated Role of Transcranial Ultrasound Neuromodulation in Ischemic Stroke: From Clinical and Basic Research

Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment

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