The Effect of Low-Intensity Shock Wave Therapy on Moderate Erectile Dysfunction: A Double-Blind, Randomized, Sham-Controlled Clinical Trial

Editorial Comment: The effect of low-intensity shock wave therapy on moderate erectile dysfunction: A double-blind, randomized, sham-controlled clinical trial

“…This very interesting article by Kalyvianakis et al, ( 6 ) offers another step in our long journey ahead. Through a double-blind, randomized clinical trial controlled by Sham, the effect of Low Intensity Shockwave Therapy on moderate erectile dysfunction was evaluated.…”

Regenerative Therapy in Sexual Medicine: The Hard Facts

“…3 Although the exact mechanism by which LI-SWT plays a regenerative role in ED has not been concretely defined, there is evidence that its effects are due to improved endothelial function, regeneration of nerve fibers, angiogenesis, and corporal tissue remodeling. 4,5 This is a result of shock waves producing microbubbles, which induce sheer stress that activates biological pathways that cause increased expression of growth factors. 4 There is an important distinction that must be made between shock waves and radial waves, which are both advertised for their use in ED.…”

This Month in Adult Urology

“…Kalyvianakis et al (page 388) from Greece report on the first sham-controlled, double-blinded randomized, controlled trial of low-intensity shock wave therapy (LiST) for men with moderate ED. 7 Seventy patients were randomized to 12 sessions, twice weekly for 6 weeks, of shock wave or a sham procedure and evaluated out to 3 months. The authors show benefit of LiST in the minimal clinically important difference of patient reported International Index of Erectile FunctioneErectile Function at both 1 and 3 months.…”