The effect of low intensity pulsed ultrasound on dentoalveolar structures during orthodontic force application in diabetic ex-vivo model

Alshihah, Nada; Alhadlaq, Adel; El‐Bialy, Tarek; Aldahmash, Abdullah; Bello, Ibrahim O.

doi:10.1016/j.archoralbio.2020.104883

Cited by 9 publications

(5 citation statements)

References 73 publications

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“…As above, the number of odontoblasts, as well as periodontal ligament cells, increased. On the tension side, bone remodeling was enhanced, whereas the number of resorption pits increased on the compression side [337]. LIPUS also augments bone formation in the context of osseointegration of dental implants in mice [338].…”

Section: May the Force Be With You: Mt And Its Implications For Periodontal Regenerationmentioning

confidence: 98%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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Among oral tissues, the periodontium is permanently subjected to mechanical forces resulting from chewing, mastication, or orthodontic appliances. Molecularly, these movements induce a series of subsequent signaling processes, which are embedded in the biological concept of cellular mechanotransduction (MT). Cell and tissue structures, ranging from the extracellular matrix (ECM) to the plasma membrane, the cytosol and the nucleus, are involved in MT. Dysregulation of the diverse, fine-tuned interaction of molecular players responsible for transmitting biophysical environmental information into the cell’s inner milieu can lead to and promote serious diseases, such as periodontitis or oral squamous cell carcinoma (OSCC). Therefore, periodontal integrity and regeneration is highly dependent on the proper integration and regulation of mechanobiological signals in the context of cell behavior. Recent experimental findings have increased the understanding of classical cellular mechanosensing mechanisms by both integrating exogenic factors such as bacterial gingipain proteases and newly discovered cell-inherent functions of mechanoresponsive co-transcriptional regulators such as the Yes-associated protein 1 (YAP1) or the nuclear cytoskeleton. Regarding periodontal MT research, this review offers insights into the current trends and open aspects. Concerning oral regenerative medicine or weakening of periodontal tissue diseases, perspectives on future applications of mechanobiological principles are discussed.

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Section: May the Force Be With You: Mt And Its Implications For Periodontal Regenerationmentioning

confidence: 98%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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“…Past experiments have shown that in diabetic rat fracture models, LIPUS can increase the expression of growth factors in the diabetic group and promote cartilage formation and angiogenesis ( 127 ). An experiment aimed at the effect of LIPUS on the alveolar structure in the process of orthodontic force in diabetic patients found that the application of LIPUS treatment, 10 minutes a day for one week, can promote normal and diabetic mandibular slice organ culture (MSOCs) bone remodeling and restoration of cementum and dentin ( 128 ). Although we believe that ultrasound has clinical potential in promoting bone healing in patients with diabetes and can even be used in the dental field, more experiments are still needed to prove and explore the underlying mechanism.…”

Section: Physical Therapiesmentioning

confidence: 99%

Challenges to Improve Bone Healing Under Diabetic Conditions

2022

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Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc. Improving bone healing in diabetic patients has important clinical significance in promoting fracture healing and improving bone integration. In this paper, we reviewed the methods of improving bone healing under diabetic conditions, including drug therapy, biochemical cues, hyperbaric oxygen, ultrasound, laser and pulsed electromagnetic fields, although most studies are in preclinical stages. Meanwhile, we also pointed out some shortcomings and challenges, hoping to provide a potential therapeutic strategy for accelerating bone healing in patients with diabetes.

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“…Investigadores que estudiaban pacientes con diabetes mellitus (DM) en relación al movimiento dentario, hallaron que se produce una disminución del mismo, asociada a un retraso en la acumulación de osteoclastos, debido a una tardía remodelación y eliminación del tejido hialinizado (15). Mientras otro estudio demostró que el hueso alveolar recién formado en DM no presenta las mismas características estructurales en comparación con animales normoglicémicos durante el movimiento dental ortodóntico, lo cual concuerda con lo autores mencionados anteriormente (16).…”

Section: Tratamientos Sistémicos/endocrinosunclassified

Revisión bibliográfica: Investigación de ortopedia y ortodoncia en animales como modelos de experimentación

Pérez-Flores

Alarcon

Lai

et al. 2021

Rev Estomatol Herediana.

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El objetivo de esta revisión de literatura es identificar los estudios de ortodoncia y ortopedia en modelos animales. Describiendo su metodología, analizando los resultados y comparando los diferentes estudios. El uso frecuente de animales de experimentación ha permitido el desarrollo de la biomedicina a lo largo de la historia de la humanidad. El modelo de estudio más utilizado en investigaciones de medicina y odontología con modelo animal, han sido las ratas. Los campos más estudiados son ortodoncia; interacción de los movimientos de ortodoncia con otros procesos biológicos o agentes que influyen como cirugías, toma de medicamentos o enfermedades. En cambio, en el área de ortopedia no ha presentado tantas investigaciones en modelo animal, por lo que podría ser un área a desarrollar en futuras investigaciones.

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The effect of low intensity pulsed ultrasound on dentoalveolar structures during orthodontic force application in diabetic ex-vivo model

Cited by 9 publications

References 73 publications

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

Challenges to Improve Bone Healing Under Diabetic Conditions

Revisión bibliográfica: Investigación de ortopedia y ortodoncia en animales como modelos de experimentación

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