The effect of low-dose supplementation with n-3 polyunsaturated fatty acids on some risk markers of coronary heart disease

Lervang, Hans Henrik; Schmidt, Erik Berg; Møller, Jesper M.; Svaneborg, Niels; Varming, Kim; Madsen, Poul Thøis; Dyerberg, Jørn

doi:10.3109/00365519309086635

Cited by 13 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28,39 Further, an increase in the n-3 LCPUFA series is negatively correlated with n-6 LCPUFA and the ratio of n-6 : n-3 LCPUFA of fishconsumers is much less (3.21%) than that of non-fishconsumers (14.34%). 56,57 Moreover, previous studies from the Indian region reported that the mean distributions of blood lipids and blood pressures were significantly lower in fish-consuming groups than in non-fish-consuming groups. The accumulation of n-3 LCPUFA in the serum phospholipids of the membranes was associated with a reciprocal decrease in the n-6 LCPUFA, especially arachidonic acid (20:4 n-3), due to the inhibitory effect of n-3 LCPUFA in the synthesis of arachidonic acid from linoleic acid (18:2 n-6).…”

Section: Discussionmentioning

confidence: 95%

“…52,54,55 The hypolipidemic effect of dietary fish has been well documented. 56,57 Moreover, previous studies from the Indian region reported that the mean distributions of blood lipids and blood pressures were significantly lower in fish-consuming groups than in non-fish-consuming groups. 40,41 Although serum total cholesterol is an independent risk factor for premature CVD, its atherogenecity is markedly influenced by the levels of lipoprotein present in cholesterol.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Influence of fish consumption on the distribution of serum cholesterol in lipoprotein fractions: comparative study among fish‐consuming and non‐fish‐consuming populations

Bulliyya

2002

Asia Pac J Clin Nutr

View full text Add to dashboard Cite

The objective of this study was to investigate serum lipoprotein levels in order to assess cardiovascular disease (CVD) risk factors between fish-consuming populations and non-fish-consuming populations, as it has been speculated that fish intake reduces CVD risk. A representative sample of one thousand subjects (529 men and 471 women) were selected, with ages ranging from 20 to 70 years, from 40 villages belonging to fish-consuming (500) or non-fish-consuming (500) populations. Serum lipoprotein lipids such as total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were analysed biochemically using standard procedures. The ratios of TC: HDL-C and LDL-C: HDL-C were computed. Mean values of serum LDL-C and the ratios of LDL-C: HDL-C and TC: HDL-C were significantly lower and HDL-C levels were higher in fish-consumers than in non-fish-consumers. The concentrations of HDL-C decreased with increasing age, while the reverse was true for LDL-C and for the LDL-C: HDL-C and TC: HDL-C ratios. There were significant sex differences for certain age groups in both of the population groups. The 5th, 50th and 95th percentile cut-off values for these parameters were lower in fish-consumers than in non-fish-consumers. The prevalence of individuals at risk of CVD because of low HDL-C (<35 mg/dL), high LDL-C (>130 mg/dL) and their atherogenic ratios (LDL-C: HDL-C >3.5 and TC: HDL-C>4.5) was significantly greater in non-fish-consumers. This study highlights that the fish-consuming population had a lower atherogenic risk than the non-fish-consuming population. The intake of fish may have substantial implications for public health and health economy by decreasing the risk of CVD. However, more studies are warranted to better define the mechanisms of cardioprotection by dietary fish and fish oils.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Influence of fish consumption on the distribution of serum cholesterol in lipoprotein fractions: comparative study among fish‐consuming and non‐fish‐consuming populations

Bulliyya

2002

Asia Pac J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Dietary intervention studies demonstrated that the consumption of up to 0.9 g n-3 VLCPUFA daily Ð corresponding to a daily intake of 40 ± 60 g ®sh of mixed type (lean, intermediate, and fatty) Ð has no signi®cant impact on classical CHD risk factors such as low density lipoprotein cholesterol and ®brinogen, or most other putative mediators of atherothrombogenesis (Lervang et al, 1993;Schmidt et al, 1996;Marckmann et al, 1997). The postprandial triglyceride pro®le is one obvious exception.…”

Section: Discussionmentioning

confidence: 99%

Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies

Marckmann¹,

1999

View full text Add to dashboard Cite

Objectives: To review all prospective cohort studies examining the relationship between ®sh intake and coronary heart disease mortality, and to assess the strength and consistency of their ®ndings. Design: Systematic review of studies based on individual records of ®sh or n-3 polyunsaturated fatty acid consumption and coronary heart disease death. Studies were given scienti®c quality scores and divided into categories of high, intermediate, or insuf®cient quality. Main outcome measure: Coronary heart disease mortality. Results: Eleven studies were identi®ed. The cohorts counted a total of 116 764 individuals. Of four studies judged to be of high quality, the two largest (n 44 895 and 20 051) were performed in populations at low risk of coronary heart disease. They found no protective effect of ®sh consumption. The other two high-quality studies were relatively small (n 852 and 1822) and included individuals at higher risk. They both found an inverse relationship between ®sh consumption and coronary heart disease death, suggesting that 40 ± 60 g ®sh per day is optimal and associated with a risk reduction of 40 ± 60%. Results of four studies of intermediate quality support that ®sh consumption is inversely associated with coronary heart disease mortality in high-risk populations only. Three studies were judged to be of insuf®cient quality to be used for drawing conclusions. Conclusions: Fish consumption is not associated with reduced coronary heart disease mortality in low-risk populations. However, ®sh consumption at 40 ± 60 g daily is associated with markedly reduced coronary heart disease mortality in high-risk populations. The underlying biochemical mechanism is not known and causal inference premature.

show abstract

“…Conversely, when they are administered at a dose which is low but sufficient to reduce CHD mortality in humans, they lose a high proportion of their properties. They no longer exert any hypocholesterolemic or hypotriglyceridemic effects [156,157], and they lose their antiaggregation and fibrinolytic properties [156,157]. Their beneficial action on CHD mortality thus occurs through a different mechanism.…”

Section: Blood Risk Factorsmentioning

confidence: 99%

Dietary n-3 polyunsaturated fatty acids and coronary heart disease-related mortality: a possible mechanism of action

Demaison¹,

Moreau²

2002

Cellular and Molecular Life Sciences (CMLS)

105

View full text Add to dashboard Cite

Epidemiological and interventional studies indicate that dietary n-3 PUFA reduces mortality due to coronary heart disease (CHD). They act at a low dose, since one or two meals with fatty fish per week is sufficient to provide protection when compared with no fish intake. These fatty acids are effective in providing primary prevention in low- and high-risk subjects and secondary prevention. At high doses, dietary n-3 PUFAs have several beneficial properties. First, they act favourably on blood characteristics: they are hypocholesterolemic and hypotriglyceridemic; they reduce platelet aggregation; they exhibit antithrombotic and fibrinolytic activities; they reduce blood viscosity and they exhibit antiinflammatory action. Second, they reduce ischemia/reperfusion-induced cellular damage. This effect is apparently due to the incorporation of eicosapentaenoic acid in membrane phospholipids. Third, they reduce ischemia and reperfusion arrhythmias. All the effects exerted by n-3 PUFAs at high doses are incompatible with the beneficial action on CHD mortality in humans observed at low doses, where their main properties are related to circulation in the form of free fatty acids. Numerous experimental studies have indicated that low concentrations of exogenous n-3 PUFAs reduce the severity of cardiac arrhythmias. This effect is probably responsible for the protective action of n-3 PUFA on CHD mortality. Further studies are necessary to confirm this assumption in animals. Such studies should take account of the fact that only a low dose of n-3 PUFA (20 mg/kg/day) is necessary to afford protection. Furthermore, since the beneficial effect of n-3 PUFAs on CHD mortality is observed in fish eaters versus no-fish eaters, and since populations in industrialised countries consume excess n-6 PUFAs, control animals in long-term dietary experiments should be fed a diet with only n-6 fatty acids as a source of PUFAs.

show abstract

The effect of low-dose supplementation with n-3 polyunsaturated fatty acids on some risk markers of coronary heart disease

Cited by 13 publications

References 23 publications

Influence of fish consumption on the distribution of serum cholesterol in lipoprotein fractions: comparative study among fish‐consuming and non‐fish‐consuming populations

Influence of fish consumption on the distribution of serum cholesterol in lipoprotein fractions: comparative study among fish‐consuming and non‐fish‐consuming populations

Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies

Dietary n-3 polyunsaturated fatty acids and coronary heart disease-related mortality: a possible mechanism of action

Contact Info

Product

Resources

About