The Effect of Low-dose Orlistat (60 mg Twice Daily) on Weight-loss and Markers of Metabolic Disease in Obese Subjects: A Preliminary Report

Clinical Efficacy of A Nutraceutical Approach for the Management of Dyslipidemia in Metabolic Disorders: A One-Year Treatment With Armolipid Plus

“…For policosanol, it has been suggested a mild inhibition of the HMG-CoA reductase, but this action has not been confirmed [24] . Returning to explain the unforeseen exciting results of our study, it appears likely that while monacolin K with its statin-like mechanism has induced a reduction of total-Ch (and well of non-HDL Ch) around 10-20% at the most, as widely reported in other papers [24][25] as well as in our experience with other nutraceuticals [21] ; remains to be understood how and why we have reached a so great decrease of total -CH in comparison with other trials, not justified by the lower LDL-Ch decrease and the contemporary parallel decrease of non-HDL Ch.…”

“…The effects of berberine on lipid and glucose metabolism [17,[23][24][35][36][37][38][39] have been reported for many decades by Chinese medicine; furthermore, the synergistic effect derived from the interaction between monacolin and berberine on cholesterol reduction is a defined assumption so far [17,[23][24] . Conceivably, the complementary action of berberine and monacolin has very likely determined the concurrent heavy decrease of total-and non-HDL cholesterol in our patients by removing lipids (chiefly cholesterol) vehicolated by LDL as well VLDL lipoproteins [21] .…”

“…In the morning (before 8 a.m., after an overnight fast of at least 12 hours), we checked weight and Body Mass Index (kg/m 2 ). Other anthropometric measurements included skinfold thickness (biceps, triceps, subscapular and suprailiac skinfolds) and circumferences at waist, hip, wrist, and mid-upper arm) [21] .…”

“…Plasma was divided into aliquots and stored at -70°C until assay. The measurement of plasma glucose and lipids was performed by standard enzymatic colorimetric methods (COBAS 6000 analyzer, Roche Diagnostics) [21] . HbA1c was evaluated by ion-exchange chromatography on HPLC-723 G7 analyzer (TOSOH Bioscience) [21] .…”