The effect of low-dose Cordyceps on ischemia-reperfusion injury of the kidney in rats

Abstract

Objective: None of studies have been conducted in terms of demonstrating the same effect with the low dose in cordycepin. In our study, we analyzed the histopathological and biochemical changes of low-dose Cordycepin(c) on a rat model in the kidney. Materials and methods: Twenty-four male Wistar Albino rats were randomly allocated to three groups (n = 8): the sham-control group (Group 1), the renal I/R-untreated (Group 2) group, and the I/R-C-treated (Group 3) group. Cordyceps was administered intraperitoneally at 5 mg/kg twice. Renal histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: In blood and tissue biochemistry, it was observed that IL-1 Beta, IL 6, TNF alpha, MDA, TOS, and OSI increased in Group 2 and decreased in Group 3. It was determined that TAS values were increased in Group 3, and decreased in Group 2. In the histopathological evaluation, while Group 1 was evaluated as normal, significant kidney damage was detected in Group 2. It was determined that there was a significant decrease in kidney damage in Group 3. Conclusion: These results suggest that low dose Cordycepin was as effective as normal dose on renal ischemic reperfusion and reduction of damage.

Efectos protectores de Passiflora incarnata en la lesión por isquemia-reperfusión en la torsión testicular: un estudio experimental en un modelo de rata

“…The study of Okur et al 5 found that cordycepin significantly reduced TNF-α and MDA levels and increased TAS while decreasing TOS in the testicular tissue of rats subjected to I/R, compared to the I/R group without cordycepin treatment, indicating its potential protective effect against I/R-induced testicular damage. Özgür et al 6 study highlighted that both ibuprofen and roflumilast offer protective effects as antioxidant treatments in testicular ischemia-reperfusion injury, with roflumilast demonstrating superior benefits.…”

“…Given that the length of the torsion is strongly related to the chance of losing a testicle, prompt surgical intervention is absolutely necessary. In an effort to reduce IR damage related to TT, several strategies have been used such as cordycepin, roflumilast and ibuprofen, arbutin, thymoquinone, and syringic acid [4][5][6][20][21][22] . However this is the first study To the best of our knowledge, this is the first study administering PI to rats in a testis torsion-induced model.…”

“…The principal factors contributing to the damage of testicular parenchymal tissue include elevated reactive oxygen species (ROS) levels, increased calcium levels within mitochondria, and cellular apoptosis. In an effort to limit the negative impacts of ischemia-reperfusion injury, a variety of medical treatments, used in tandem with manual or surgical detorsion, are currently under investigation [4][5][6] .…”

Cordycepin inhibits kidney injury by regulating GSK‐3β‐mediated Nrf2 activation

“…[4,5] Cordycepin (COR), the main active component of C. sinensis, is also a kind of pharmacologically active small molecules, whose role and targets in kidney injury have rarely been reported so far. [6,7] Despite being one of the most effective chemotherapeutics for treating solid tumors, the application of cisplatin (CDDP) in chemotherapy is restricted by its histotoxicity, especially kidney toxicity, with CDDP-induced acute kidney injury (AKI) seriously affecting the chemotherapeutic efficacy and quality of life of patients. [8] Studies have found that ferroptosis is one of the primary mechanisms whereby CDDP induce kidney injury, while inhibiting ferroptosis can inhibit CDDP-induced kidney injury.…”

“…[ 4,5 ] Cordycepin (COR), the main active component of C. sinensis , is also a kind of pharmacologically active small molecules, whose role and targets in kidney injury have rarely been reported so far. [ 6,7 ]…”