The Effect of Low and Moderate Exercise on Hyperuricemia: Protocol for a Randomized Controlled Study

Abstract

BackgroundHyperuricemia (HUA) is a metabolic disease by purine metabolism disorders. It is a risk factor for many chronic diseases, including diabetes, hypertension, and heart disease. Studies have shown that exercise can effectively reduce serum uric acid (SUA), but the optimal exercise dose, intensity, and mode of exercise for improving HUA have not been verified in clinical studies. Therefore, this study aims to explore the effect of different exercise intensities in improving SUA of patients with HUA.Methods and AnalysisA randomized, single-blind, parallel controlled trial will be conducted in this study. 186 HUA patients who meet the inclusion criteria will be randomly divided into a 1:1:1 ratio (1): control group (2), low-intensity exercise group (brisk walking, 57-63% maximum heart rate, 150 min/week, 12 months), and (3) moderate-intensity exercise group (jogging, 64-76% maximum heart rate, 150 min/week, 12 months). The three groups of subjects will receive the same health education and prohibition of high-purine diet during the intervention period. The primary outcomes will be SUA concentration, SUA concentration change (mg/dL), SUA change rate (%), and the proportion of HUA patients. Secondary outcomes will include anthropometric parameters (body weight, waist circumference, hip circumference, BMI); physiological indicators (blood pressure, grip, vital capacity, maximum oxygen); biochemical indicators (blood lipid, blood sugar, liver enzyme, creatinine, and blood urea nitrogen). Each group of patients will go through an assessment at baseline, 3rd, 6th, and 12th months.DiscussionThis study will evaluate the effect of 12-month low-intensity exercise and moderate-intensity exercise on HUA patients. We hypothesize that both low-intensity and moderate-intensity exercise would improve HUA as compared with no-exercise control, and that moderate-intensity exercise would be more effective than low-intensity exercise in improving HUA. These results can provide a basis for the current physical activity guidelines for HUA’s healthy lifestyle management.Ethics and DisseminationThis study has been approved by the Ethical Review Committee of the Shanghai University of Sport (approval number: 102772020RT005). Informed consent will be obtained from all participants or their guardians. The authors intend to submit the study findings to peer-reviewed journals or academic conferences to be published.Clinical Trial RegistrationChinese Clinical Trial Registry, identifier ChiCTR2100042643.

Safety and efficacy evaluation of personalized exercise prescription during chemotherapy for lung cancer patients

“…Aerobic and resistance exercises can significantly improve blood lipid levels and reduce mortality rates related to cardiovascular diseases 49 . Exercise can improve hyperuricemia, with moderate‐intensity exercise being more effective than low‐intensity exercise in this regard 50 . Exercise can improve anemia through multiple mechanisms, including bone marrow stimulation, improving the hematopoietic microenvironment, and controlling levels of inflammation and hormones 51,52 .…”

The dose-response relationship of serum uric acid with Dyslipidaemia and its components: a cross-sectional study of a Chinese multi-ethnic cohort

“…Furthermore, both regular and high-intensity aerobic exercise appeared to be beneficial in improving the blood lipid status [ 55 ]. A randomized controlled study showed that moderate-intensity exercise (jogging) was more beneficial than low-intensity exercise (brisk walking) in reducing the risk of hyperuricemia [ 56 ]. Strategies capable of truly increasing the SUA levels and dyslipidaemia must be researched further.…”

Nonlinear dose-response association of moderate-to-vigorous physical activity with hyperuricemia in US adults: NHANES 2007–2018

“…SUA from 2015 to 2018 was measured by DxC800 and DxC660i using time endpoint method. HUA was defined as SUA levels >7mg/dL in males and >6mg/dL in females in two fasting tests on different days under the condition of normal purine diet [ 7 ].…”

“…HUA has been confirmed as an important risk factor for gout. Furthermore, HUA is also one of the independent risk factors for several chronic diseases [ 7 ]. Studies showed the incidence of coronary heart disease, hypertension and diabetes respectively increased by 12% [ 8 ], 13% [ 9 ] and 17% [ 10 ] while the SUA level increases by 60mmol/L.…”