The effect of lorcainide on arrhythmias and survival in patients with acute myocardial infarction: an example of publication bias

Cowley, Alison; Skene, A. M.; Stainer, K.; Hampton, John R.

doi:10.1016/0167-5273(93)90279-p

Cited by 62 publications

(43 citation statements)

References 7 publications

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“…In the field of cancer chemotherapy, such publication bias has been demonstrated by comparing the results from studies identified in a literature search with those contained in an international trials registry 43,44 . In cardiovascular medicine, investigators in 1980 who found an increased death rate among patients with acute myocardial infarction treated with a class 1 anti-arrhythmic agent dismissed it as a chance finding and did not publish their trial at the time 45 . As discussed by Iain Chalmers, their findings would have contributed to a more timely detection of the increased mortality that has since become known to be associated with the use of class I anti-arrhythmic agents 46 .…”

Section: Biased Dissemination Of Research Findingsmentioning

confidence: 99%

Uses and abuses of meta-analysis

2001

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-Meta-analysis, the statistical combination of results from several studies to produce a single estimate of the effect of a treatment, continues to attract controversy. We illustrate the potentials and pitfalls of meta-analysis of controlled clinical trials. Cumulative meta-analysis demonstrates that this technique could prevent delays in the introduction of effective treatments. Meta-analyses are, however, liable to numerous biases both at the level of the individual trial ('garbage in, garbage out' ) and the dissemination of trial results (publication bias). We argue that meta-analysis should be performed only within the framework of systematic reviews -that is, reviews prepared using a systematic approach to minimise bias and address the combinability of studies. Many of the groups ... are far too small to allow of any

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Section: Biased Dissemination Of Research Findingsmentioning

confidence: 99%

Uses and abuses of meta-analysis

2001

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“…More deaths were observed in the lorcainide group than in the placebo group (9/48 versus 1/47). 211 The trial results were not published because the development of lorcainide was stopped for 'commercial reasons'. About a decade later, an increased mortality was observed among patients treated with the related agents, encainide and flecainide, in two trials.…”

mentioning

confidence: 99%

Dissemination and publication of research findings: an updated review of related biases

Song

Parekh²,

Hooper³

et al. 2010

Health Technol Assess

805

682

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“…their trial at the time. 60 As discussed in Chapter 24 their findings would have contributed to a more timely detection of the increased mortality that has since become known to be associated with the use of class I anti-arrhythmic agents. 19,61 The proportion of all hypotheses tested for which the null hypothesis is truly false is of course unknown and surveys of published results can therefore only provide indirect evidence of publication bias.…”

Section: Box 33 a Demonstration Of Publication Biasmentioning

confidence: 99%