The Effect of Lonicera Japonica Thunberg on Inflammatory Factor Expression Associated with Atherosclerosis

양, 지혜; 유, 호룡; 김, 윤식; 설, 인찬

doi:10.22246/jikm.2021.42.1.25

Cited by 1 publication

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References 11 publications

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“…風熱感冒, 溫病發熱, 喉痹, 丹毒, 癰腫疔瘡, 熱毒血痢 등을 치 료하며 12) , 상기도 감염증, 피부 화농성 감염, 부인과 감염증 등에 사용된다 30) . 관련 연구로는 glutamate에 의한 신경세포 사멸 보호 17) , 인간 제대정맥 내피세포 (HUVEC)에서 죽상동맥경화증과 관련된 염증인자 발현 억제 31) , MIF 활성을 조절하여 COX-2 및 MMP-9의 생성 억제를 통한 류마티스성 관절염 치 (350)…”

Section: 유전자 발현량unclassified

The Study on Antioxidant and Anti-inflammatory Effects of Taraxacum platycarpum H. Dahlstedt, Lonicera japonica Thunberg and Leonurus japonicus Houtt. Complex

Huh,

Kim

2023

J Korean Med

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Objectives: This study was designed to experiment with the antioxidant and anti-inflammatory effects of Taraxacum platycarpum H. Dahlstedt, Lonicera japonica Thunberg, and Leonurus japonicus Houtt. complex (TLL) in LPS-induced RAW264.7 cell.Methods: The antioxidant activity of TLL was measured by FRAP assay, DPPH radical scavenging activity, ABTS radical scavenging activity. Total polyphenol and flavonoid contents of TLL were measured by using standard methods. The anti-inflammatory effects of TLL were measured by NO production, biomarker production (PGE2, IL-1β, IL-6, TNF-α), mRNA expression level (iNOS, COX-2, IL-1β, IL-6, TNF-α) and protein expression level (ERK, JNK, p38).Results: Total polyphenol and flavonoid contents in TLL were 58.03±1.02 ㎎ of Gallic acid equivalents (GAE)/g and 16.58±0.60 mg of Quercetin equivalents (QE)/g respectively. In FRAP assay, DPPH and ABTS radical scavenging activity, a concentration-dependent increase in TLL was observed. To explore antioxidant and anti-inflammatory effects of TLL, RAW 264.7 cells were treated with TLL and LPS for 24 hours. Cell viability of RAW 264.7 cells were measured by adding EZ-Cytox, It was remarkably increased at 50, 100, 200 ㎍/㎖ concentrations of TLL. NO, ROS, iNOS, IL-1β, IL-6, TNF-α, ERK, JNK and p38 were remarkably decreased at 50, 100, 200 ㎍/㎖ concentrations of TLL compared to the control group. PGE2 and COX-2 were remarkably decreased at 100, 200 ㎍/㎖ concentrationsConclusion: These results suggest that TLL complex has antioxidant and anti-inflammatory effects.

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Section: 유전자 발현량unclassified

The Study on Antioxidant and Anti-inflammatory Effects of Taraxacum platycarpum H. Dahlstedt, Lonicera japonica Thunberg and Leonurus japonicus Houtt. Complex

Huh,

Kim

2023

J Korean Med

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The Effect of Lonicera Japonica Thunberg on Inflammatory Factor Expression Associated with Atherosclerosis

Cited by 1 publication

References 11 publications

The Study on Antioxidant and Anti-inflammatory Effects of Taraxacum platycarpum H. Dahlstedt, Lonicera japonica Thunberg and Leonurus japonicus Houtt. Complex

The Study on Antioxidant and Anti-inflammatory Effects of Taraxacum platycarpum H. Dahlstedt, Lonicera japonica Thunberg and Leonurus japonicus Houtt. Complex

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