The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls—A randomized placebo-controlled, double-blind fMRI study

Guse, Birgit; Falkai, Peter; Gruber, Oliver; Whalley, Heather C.; Gibson, Lydia; Hasan, Alkomiet; Obst, Katrin; Dechent, Peter; McIntosh, Andrew M.; Suchan, Boris; Wobrock, Thomas

doi:10.1016/j.bbr.2012.09.034

Cited by 66 publications

(51 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sham rTMS procedure was more heterogeneous. One study used a sham procedure using the same stimulation parameters as the real stimulation, although with the coil held in a single wing-tilt position at 90 degrees (Barr et al, 2013), or with the coil positioned 5 cm latero-caudal to F3 and with one wing angled 45 degrees away from the skull (Guse et al, 2013).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Regarding blinding, half of the studies were double-blinded (Barr et al, 2013;Gaudeau-Bosma et al, 2012;Guse et al, 2013;Keeser et al, 2013;Oliveira et al, 2013;Teo et al, 2011) and the other half were double single-blinded, i.e., the subject and the evaluator were blinded to the allocation group, but not the person applying the stimulation. The time period between stimulation conditions ranged from at least one hour to more than one week (Mulquiney, Hoy, Daskalakis, & Fitzgerald, 2011).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…(Boggio et al, 2006) and (Oliveira et al, 2013))or were on a stable dose (Barr et al, 2013;Guse et al, 2013). Psychiatric patients were screened using standard questionnaires and/or psychiatric interviews.…”

Section: Quality Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Brunoni

Vanderhasselt

2014

Brain and Cognition

551

411

View full text Add to dashboard Cite

Recent studies have used non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), to increase dorsolateral prefrontal cortex (DLPFC) activity and, consequently, working memory (WM) performance.. However, such experiments have yielded mixed results, possibly due to small sample sizes and heterogeneity of outcomes. Therefore, our aim was to perform a systematic review and metaanalyses on NIBS studies assessing the n-back task, which is a reliable index for WM. From the first data available to February 2013, we looked for sham-controlled, randomized studies that used NIBS over the DLPFC using the n-back task in PubMed/MEDLINE and other databases. Twelve studies (describing 33 experiments) matched our eligibility criteria. Active vs. sham NIBS was significantly associated with faster response times (RT), higher percentage of correct responses and lower percentage of error responses. However, meta-regressions showed that tDCS (vs. rTMS) presented an improvement only in RT. This could have occurred in part because almost all tDCS studies employed a crossover design (possibly more employed in tDCS over rTMS due to the reliable tDCS blinding) -this factor (study design) was also associated with no improvement in correct responses in the active vs. sham groups. To conclude, rTMS over the DLPFC significantly improved all measures of WM performance whereas tDCS significantly improved RT, but not the percentage of correct and error responses. Mechanistic insights on the role of DLPFC in WM are further discussed, as well as how NIBS techniques could be used in neuropsychiatric samples presenting WM deficits, such as major depression, dementia and schizophrenia.

show abstract

Section: Quality Assessmentmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Brunoni

Vanderhasselt

2014

Brain and Cognition

551

411

View full text Add to dashboard Cite

show abstract

“…Relatively few studies to date have demonstrated such effects (Preston et al 2010;Esslinger et al 2014;Hoy et al 2015), with others finding no significant effects (Gaudeau-Bosma et al 2013;Guse et al 2013). Given the large variability in cognitive tasks, stimulation protocols, and targeted cortical sites in these studies, the effectiveness of TMS in enhancing WM remains an open question.…”

mentioning

confidence: 99%

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

et al. 2016

View full text Add to dashboard Cite

“…Two previous studies have investigated the effect of rTMS treatment in patients with schizophrenia on neuronal activation [26,27]. Both of the studies applied rTMS treatment to the left DLPFC.…”

Section: Effect Of Rtms On Negative Symptomsmentioning

confidence: 99%

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Sayar¹,

Bulut²,

Tarhan³

2015

J Neurol Neurol Sci Disord

View full text Add to dashboard Cite

The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls—A randomized placebo-controlled, double-blind fMRI study

Cited by 66 publications

References 45 publications

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Contact Info

Product

Resources

About