The effect of long‐term glycaemic control on serum lipoprotein(a) levels in patients with Type 2 diabetes mellitus

Song, Ki‐Ho; Ahn, Yu‐Bae; Yoon, Kun‐Ho; ‐Y., B.; Lee, K. ‐W.; Son, Hyun-Shik; Kang, Sheng

doi:10.1046/j.1464-5491.1999.00183.x

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…We did not find a significant negative correlation of Lp(a) with elevated triglyceride values in DM. There was also no influence on the serum Lp(a) concentration of diabetic metabolic control monitored by fasting blood glucose and HbA 1c , as expected due to the observations over time [28].…”

Section: Discussionsupporting

confidence: 61%

Influence of lipoprotein(a) on restenosis after femoropopliteal percutaneous transluminal angioplasty in Type 2 diabetic patients

Maca¹,

Ahmadi²,

Derfler³

et al. 2002

Diabetic Medicine

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Section: Discussionsupporting

confidence: 61%

Influence of lipoprotein(a) on restenosis after femoropopliteal percutaneous transluminal angioplasty in Type 2 diabetic patients

Maca¹,

Ahmadi²,

Derfler³

et al. 2002

Diabetic Medicine

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“…Meanwhile, among patients with T2D, if glucose levels are normalized after long-term glycaemic control, the serum Lp(a) levels were not signifi cantly changed compared without hypoglycemic treatment ( 23,24 ). In our present study, among 1,775 T2D patients, 46.5% were previously diagnosed diabetes, among which 87.5% were on antidiabetic agents.…”

Section: Discussionmentioning

confidence: 41%

Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population

Ding

Song

Dai

et al. 2015

Journal of Lipid Research

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Lipoprotein (a) [Lp(a)], synthesized by the liver, is a cholesterol-laden LDL-like particle, consisting of a moiety of apo(a) covalently attached to one molecule of apoB100 via a disulfi de bond ( 1 ). The concentration of Lp(a) was found to a large extent genetically determined via variations in the LPA gene, especially the LPA kringle IV repeats, which encode apo(a) and exist in multiple copies ( 2 ). Both serum Lp(a) levels and LPA gene variants have been reported strongly associated with the risk of CVD ( 3-5 ).Because diabetes predisposes individuals toward CVD, a similar association between circulating Lp(a) levels and Abstract Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the risk of CVD. However, the relationship between serum Lp(a) and T2D is poorly characterized, especially in the Asian population. Therefore, we conducted a cross-sectional study in 10,122 participants aged 40 years or older in Jiading District, Shanghai, China. Our study found that the prevalence of T2D was decreased from 20.9% to 15.0% from the lowest quartile to the highest quartile of serum Lp(a) concentrations ( P for trend <0.0001). Logistic regression analyses showed that the odds ratios and 95% confi dence intervals of prevalent T2D for quartiles 2-4 versus quartile 1 were 0.86 (0.73-1.01), 0.88 (0.75-1.04), and 0.76 (0.64-0.90) ( P for trend = 0.0002), after adjustment for traditional confounding factors. Moreover, the risks for prevalent prediabetes, insulin resistance, and hyperinsulinemia were also decreased from the lowest to the top quartile. This inverse association between serum Lp(a) and T2D was not appreciably changed after we adjusted hypoglycemic medications or excluded the subjects with hypoglycemic and/or lipid-lowering agents and/or a history of self-reported CVD. (81321001, 81390350, 81222008, and 81130016), the Shanghai Municipal of Science and Technology (13495810200) 24 January 2015. Published, JLR Papers in Press, February 3, 2015 DOI 10.1194 Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population Abbreviations: 2 hPG, 2 h 75 g oral glucose tolerance test plasma glucose; CCHS, Copenhagen City Heart Study; CI, confi dence interval; DBP, diastolic blood pressure; FPG, fasting plasma glucose; FSI, fasting serum insulin; HbA1C, hemoglobin A1C; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment for insulin resistance; LDL-C, low density lipoprotein cholesterol; lg, logarithmically transformed; Lp(a), lipoprotein (a); MET-h/week, metabolic equivalent hours per week; OGTT, oral glucose tolerance test; OR, odds ratio; SBP, systolic blood pressure; TC, total cholesterol; WC, waist circumference; WHS , Women's Health Study. This work was supported by grants from the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health (1994DP131044), the N...

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Current Awareness

2000

Diabetes Metab. Res. Rev.

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In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Prediction; 7 Prevention; 8 Intervention: a&rpar General; b&rpar Pharmacology; 9 Pathology: a&rpar General; b&rpar Cardiovascular; c&rpar Neurological; d&rpar Renal; 10 Endocrinology & Metabolism; 11 Nutrition; 12 Animal Studies; 13 Techniques. Within each section, articles are listed in alphabetical order with respect to author (8 Weeks journals - Search completed at 19th Apr. 2000)

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The effect of long‐term glycaemic control on serum lipoprotein(a) levels in patients with Type 2 diabetes mellitus

Abstract: These results indicate that improvement of glycaemic control does not affect serum Lp(a) levels in patients with Type 2 diabetes mellitus.

Cited by 8 publications

References 20 publications

Influence of lipoprotein(a) on restenosis after femoropopliteal percutaneous transluminal angioplasty in Type 2 diabetic patients

Influence of lipoprotein(a) on restenosis after femoropopliteal percutaneous transluminal angioplasty in Type 2 diabetic patients

Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population

Current Awareness

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