The effect of local x‐ray irradiation upon the development of the anterior part of the head of the axolotl

Abstract

TWENTY-EIGHT FIGURESI n previous papers concerning the influence of local x-ray treatment on the development of young axolotls, the effects o f irradiation upon the tail (Brunst, '50a; Brunst and Figge, '51), extremities (Brunst, '50b), jaws (Brunst, SheremetievaBrunst and Figge, '52a), and teeth (Brunst, SheremetievaBrunst and Figge, ,52b) were described.The present investigation concerns two aspects of the effect of x-rays upon the development o f the anterior part of the head of axolotls. First is the general tissue reaction of the head to treatment and the effect of x-rays on the development of the eyes; second is the effect of local irradiation of the anterior part o f the head on the growth of the entire animal.

Investigation of the Lethal Effect of X-Irradiation on the Young Axolotl (Siredon mexicanum)

“…The dose of 6000 r is large enough for reaction of the retina to be observed soon after treatment. The animals receiving 3000 r of head irradiation only lived a comparatively long time, and damage to the retina and later disappearance of the eyes and teeth were seen according to our previous observations (17,18). DISCUSSION For comparison of the lethal effects of total-body and partial irradiation it is important to use doses large enough for reasonably early response but sufficiently small to allow observation of the treated animals long enough to note all gradations of postirradiation damage.…”