The effect of local control on metastatic dissemination in carcinoma of the prostate: Long-term results in patients treated with 1251 implantation

Fuks, Zvi; Leibel, Steven A.; Wallner, Kent E.; Begg, Colin B.; Fair, William R.; Anderson, Lowell L.; Hilaris, Basil S.; Whitmore, Willet F.

doi:10.1016/0360-3016(91)90668-t

Cited by 433 publications

(112 citation statements)

References 45 publications

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“…In fact, only 6.9 % of locally controlled animals developed metastasis, vs. 43% for those that failed local control. Data from human studies (for instance, Fuks et al [2], Leibel et al [3]) confirm this trend. Up to now, most of the researchers have focused on the question by investigating whether metastases were generated by the primary tumor or by the recurrent one, or whether tumors responsible for local recurrence were 'per se' more aggressive, and therefore equipped with an intrinsically higher metastatic potential.…”

Section: Introductionmentioning

confidence: 85%

Cancer metabolism and the dynamics of metastasis

Dattoli¹,

Guiot²,

Delsanto³

et al. 2009

Journal of Theoretical Biology

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Cancer growth dynamics, commonly simulated with a Gompertzian model, is analysed in the framework of a more recent and realistic model. In particular, we consider the setting of a tumor embedded in a host organ and investigate their interaction. We assume that, at least in some cases, tumor metastasis may be triggered by an 'energetic crisis', when the tumor exceeds the 'carrying capacity' of the host organ. As a consequence, dissemination of clusters of cancer cells is set in motion, with a statistical probability given by a Poisson distribution. The model, although still at a preclinical level, is fully quantitative and is applied, as an example, to the case of prostate cancer. The results confirm that, at least for the more aggressive cancers, metastasis starts very early during tumorigenesis and a quantitative link is found between the tumor's doubling time, its 'aggressiveness' and the metastatic potential.

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Section: Introductionmentioning

confidence: 85%

Cancer metabolism and the dynamics of metastasis

Dattoli¹,

Guiot²,

Delsanto³

et al. 2009

Journal of Theoretical Biology

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“…15 Significant differences in local relapse free survival were found for delivered doses Ͻ14,000 cGy in the Memorial Sloan-Kettering experience with retropubic implants 13,14 and for the transperineal approach, as reported recently by Stock et al 16 When treatment margins are too generous, rectal ulceration and fistulae may result from radiation injury. 17 Therefore, close examination of the location and magnitude of the radial distance of EPE of tumor may allow an objective means by which to plan for adequate coverage of the cancer and minimize radiation exposure of adjacent normal tissues.…”

mentioning

confidence: 83%

“…Failure to cover the entire prostate with a sufficient dose results in local tumor recurrence, 13,14 which probably is associated with a poorer distant metastasis free survival. 15 Significant differences in local relapse free survival were found for delivered doses Ͻ14,000 cGy in the Memorial Sloan-Kettering experience with retropubic implants 13,14 and for the transperineal approach, as reported recently by Stock et al 16 When treatment margins are too generous, rectal ulceration and fistulae may result from radiation injury.…”

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confidence: 99%

The radial distance of extraprostatic extension of prostate carcinoma

Davis

Pisansky

Wilson

et al. 1999

Cancer

142

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“…Local failure after radiotherapy for prostate cancer predisposes to distant metastasis (1)(2)(3). Some have argued that local failure is a surrogate for tumor aggressiveness and that patients who fail locally would have failed distantly anyway (4).…”

Section: Introductionmentioning

confidence: 99%

Radiation dose and late failures in prostate cancer

Morgan

Hanlon

Horwitz

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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Purpose-To quantify the impact of radiotherapy (RT) dose escalation on the timing of biochemical failure (BF) and distant metastasis (DM) for prostate cancer treated with RT alone.Methods and Materials-A total of 667 men with clinically localized intermediate and high risk prostate cancer treated with 3D-conformal RT alone were retrospectively analyzed. The interval hazard rates of DM and biochemical failure (BF), using ASTRO and Phoenix (Nadir+2) definitions, were determined. Median follow-up was 77 months.Results-Multivariate analysis showed that increasing RT dose was independently associated with decreased ASTRO BF (P<.0001), Nadir+2 BF (P=.001), and DM (P=.006). The preponderance (85%) of ASTRO BF occurred at ≤4 years after RT, while Nadir+2 BF was more evenly spread over years 1-10, with 55% BF in ≤4 years. RT dose escalation caused a shift in the BF from earlier to later years. The interval hazard function for DM appeared to be biphasic (early and late peaks) overall and for the <74 Gy group. In patients receiving ≥74 Gy, there was a reduction in the risk of DM in both the early and late waves, although the late wave appears reduced to a greater degree.Conclusions-The ASTRO definition of BF systematically underestimates late BF due to backdating. RT dose escalation diminished and delayed BF; the delay suggests that there may still be local persistence in some patients. For DM, higher RT dose reduced both the early and late waves, suggesting that persistence of local disease contributes to both.

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The effect of local control on metastatic dissemination in carcinoma of the prostate: Long-term results in patients treated with 1251 implantation

Cited by 433 publications

References 45 publications

Cancer metabolism and the dynamics of metastasis

Cancer metabolism and the dynamics of metastasis

The radial distance of extraprostatic extension of prostate carcinoma

Radiation dose and late failures in prostate cancer

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