The effect of local application of strychnine and acetylcholine on the brain cortex after complete ischemia

Sobotka, P; Gebert, E.

doi:10.1007/bf00586906

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Sensory-evoked potentials, 20 cortical steady potentials, 1 strychnine-induced spikes 21 and pyramidal tract responses 3 persist for some time after EEG activity is abolished during hypoxia. In agreement with these observations we also found persistence of PTRs after disappearance of EEG activity.…”

Section: Discussionmentioning

confidence: 99%

Pyramidal tract responses (PTR) during hypoxia and hypotension.

Sutter¹,

Wiederholt²

1976

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Sundt TM Jr: Clip-grafts for aneurysm and small vessel surgery. Part 4:Relative application to various aneurysms and repair of anterior communicating aneurysms using a right-angle clip holder. SUMMARY In rats with unilateral carotid artery ligation pyramidal tract responses were studied during hypoxia and during trimethaphan-induced hypotension. Observations on EEG activity during hypoxia suggest that unilateral carotid artery ligation produces a more severe perfusion defect in lateral portions of the hemisphere. During hypoxia and during trimethaphan-induced hypotension indirect PTRs disappeared first from the hemisphere on the side of carotid artery ligation and next from the opposite hemisphere. This was followed by loss of direct PTRs in the same order. Animals could not be resuscitated once the direct PTR from the non-ligated hemisphere had disappeared. Hypotension appears to be a late contributing factor in impairing electrocerebral activity during hypoxia in this study.

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Section: Discussionmentioning

confidence: 99%

Pyramidal tract responses (PTR) during hypoxia and hypotension.

Sutter¹,

Wiederholt²

1976

Stroke

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“…This method, described in detail previously [Sobotka and G ebert, 1971], is based on perfusion of a completely isolated head, with blood coming through the anastomosis of a.femoralis and a.carotis from the donor dog. Venous blood from the isolated head is reinfused into the donor's femoral vein by means of a Sigma motor pump.…”

Section: Aterials a Nd M Ethodsmentioning

confidence: 99%

Electroretinogram of the Isolated Dog’s Head after Prolonged Complete Brain Ischemia

Sobotka¹,

Gebert²

1972

Ophthalmic Res

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In experiments with 34 isolated dog heads, the electroretinogram (ERG) was registered at the beginning and after the end of complete normothermic brain ischemia lasting for 20, 30, 45 or 60 min. Compared with the EEG, the survival time of the ERG is significantly longer and the latency of recovery significantly shorter. Smaller but also significant differences persist even if the survival and reappearance of typical complex ERG configuration are evaluated. The greater resistance of the ERG against ischemia is explained if one assumes that the ERG is generated by different structures (individual layers of the retina and probably also surrouding nonneural tissues) which are less sensitive to oxygen deprivation than the brain cortex. The excessive values concerning the resistance of the ERG as given in the literature are partly due to the incompleteness of the ischemia and due to the concomitant evaluation of DC potantials.

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The recovery of the electrocorticogram of normothermic canine brains after complete cerebral ischemia

Hirsch

Oberdörster

Zimmer

et al. 1975

Arch. Psychiat. Nervenkr.

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Complete cerebral ischaemias of 1 to 30 min duration were performed under normothermic conditions in completely isolated canine heads perfused from a donor dog. The electrocorticogram was found to return in the reperfusion period following these complete ischaemias. The latency of recovery, i.e. the interval between the end of the complete cerebral ischaemia and the reappearance of the first cortical potentials, increased with increasing duration of the complete cerebral ischaemia; thus, the latency of recovery after a complete ischaemia of 30 min amounted to 11 to 12 hours.

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The effect of local application of strychnine and acetylcholine on the brain cortex after complete ischemia

Cited by 7 publications

References 25 publications

Pyramidal tract responses (PTR) during hypoxia and hypotension.

Pyramidal tract responses (PTR) during hypoxia and hypotension.

Electroretinogram of the Isolated Dog’s Head after Prolonged Complete Brain Ischemia

The recovery of the electrocorticogram of normothermic canine brains after complete cerebral ischemia

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