The effect of Liv-52 on liver ischemia reperfusion damage in rats

Abstract

Background: Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats. Methods: Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals. Results: Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically. Conclusions: Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.

Valuable Hepatoprotective Plants - How Can We Optimize Waste Free Uses of Such Highly Versatile Resources?

“…The plant was used to treat pulmonary and reproductive systems diseases, the biliary tract, hepatic disorders, diarrhea, and cancer ( Al-Snafi, 2016 ). The hepatoprotective activities of chicory have been established in animals and humans ( Sama et al, 1976 ; Saxena and Garg, 1979 ; Thabrew et al, 1982 ; Cimen et al, 2020 ). Inulin, a chicory root constituent, is extremely popular among consumers as a prebiotic and source of dietary fiber ( Shoaib et al, 2016 ).…”

“…Huseini et al attributed the hepatoprotective properties of the phytodrug to its antioxidant, anti-inflammatory, and immunomodulatory properties ( Huseini et al, 2005 ). Recently, it has been proven that Liv-52 could treat ischemia reperfusion-induced liver damage in rats ( Cimen et al, 2020 ).…”

Antioxidant Activity Of Rat Liver With A Low Resistance To Hypoxia After Systemic Ischemia Reperfusion

“…Ischemia-reperfusion injury often occurs after surgical interventions. Accordingly, in the contemporary literature, cases of ischemia-reperfusion damage to the liver are described, which is often observed when performing operations in the hepatobiliary region using the Pringle maneuver [1]. The latter presumes temporary compression of the hepatoduodenal ligament blood vessels [2], followed by dissection of the liver parenchyma within the ischemic zone (5-10 mm from the demarcation line).…”