The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance

Dai, Bing; Wu, Qinxuan; Zeng, Chengxi; Zhang, Jiani; Cao, Luting; Xiao, Zi-Zeng; Yang, Menglin

doi:10.1016/j.jep.2016.07.024

Cited by 88 publications

(63 citation statements)

References 18 publications

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“…In addition to MAPK and JNK, some other signaling pathways are also implicated in the regulation of glucolipid metabolism, such as AMP‐activated protein kinase (AMPK) and PI3K/AKT pathways . Exploring whether chicory inulin exerts its glucose‐control effects through these pathways, though beyond the scope of our present study, will provide interesting insights into the molecular mechanisms underlying chicory inulin's hypoglycemic action.…”

Section: Discussionmentioning

confidence: 99%

Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

Ning

Wang²,

Gao

et al. 2017

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

Ning

Wang²,

Gao

et al. 2017

Molecular Nutrition Food Res

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“…This concerns especially the traditional use of C. mas to treat disorders or complaints related to aging processes like diabetes, ischemia or cardiovascular diseases (Dinda et al, 2016; Hosseinpour-Jaghdani et al, 2017). Due to the use of C. officinalis in TCM as a component of complex drug mixtures (Chen et al, 2008; Liu et al, 2013; Dai et al, 2016), a clear assignment to effects on heart and circulation system is rather difficult. However, in preparations of TCM used for treatment of diseases often related to aging processes the fruits of C. officinalis are abundant constituents (Chinese Pharmacopoeia, 2015).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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“…21 Moreover, it is also found that SOS did not distinctly affect the activity of Akt. 22 Our results indicated that the expression of PS6 was increased in OVX mice after treatment with SOS in vivo, and the expression of PS6, P-mTOR, RUNX2, OSX, and OCN was significantly inhibited after rapamycin treatment in BMSCs. Rapamycin, a crucial drug in this study, not only is a high-efficiency inhibitor of mTORC1 but also prevents the proliferation and differ-entiation of osteoblast in MC3T3-E1 cells and primary mouse BMSCs.…”

Section: Effect Of Sos On the Ps6/mtorc1 Signaling Pathwaymentioning

confidence: 49%

Sweroside‐mediated mTORC1 hyperactivation in bone marrow mesenchymal stem cells promotes osteogenic differentiation

Ding

Jiang

Meng

et al. 2019

J of Cellular Biochemistry

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This paper aims to probe into the effect of sweroside (SOS) in osteoporosis (OP) and explains mechanisms of its molecular. Applying the ovariectomized (OVX) mouse model investigates the preventive effect of SOS against postmenopausal OP after 3 months of SOS treatment (120 mg/kg/day). Using hematoxylin and eosin (HE) staining and micro computed tomography (CT) observed the morphology of OP in each group. Immunohistochemical staining (IHC) was used to examine osteoblast markers. Experiments in vitro, bone marrow mesenchymal stem cells (BMSCs) from C57/BL6 mice were treated with SOS for 14 days. The staining of alizarin red and alkaline phosphatase activity were measured, and the presentation of osteoblast markers was detected by quantitative reverse transcription PCR. BMSCs were also treated with 1 μg/mL SOS with or without rapamycin, the expression of protein S6 (PS6), P‐mTOR, runt‐related transcription factor 2 (RUNX2), OSX, and osteocalcin (OCN) was detected by Western blotting. Experiments in vivo, HE results show that SOS can alleviate OP, CT results show that there are lower trabecular thickness, bone mineral density, and trabecular number in control OVX mice than those in the OVX + SOS group. IHC results showed that SOS can promote the expression of osteogenic markers and immunofluorescent results show that SOS can promote mTORC1 signal activation. Experiments in vitro revealed that SOS stimulated the activation of the mTORC1 signaling pathway and upregulated RUNX2, OSX, and OCN, rapamycin can reverse it. Our findings demonstrated that differentiated BMSCs into osteoblasts can be promoted by SOS via upregulating the expression of P‐mTOR, PS6, RUNX2, OSX, and OCN. SOS effectively prevented OP by hyperactivation of the mTORC1/PS6 signaling pathway.

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The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance

Cited by 88 publications

References 18 publications

Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Sweroside‐mediated mTORC1 hyperactivation in bone marrow mesenchymal stem cells promotes osteogenic differentiation

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