The effect of lithium on impulsive aggressive behavior in man

Sheard, Michael H.; Marini, James L.; Bridges, Carolyn; Wagner, Eva-Maria

doi:10.1176/ajp.133.12.1409

Cited by 314 publications

(17 citation statements)

References 11 publications

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“…Interestingly, previous studies have suggested that lithium may have strong anti-aggressive properties in humans [86,87] and anti-impulsivity properties in preclinical models [88–90]. Notably, of all current treatments for BD, long-term lithium therapy is the only intervention associated with decreased rates of suicidal behavior and mortality in well-conducted meta-analytic reviews [91–93].…”

Section: Endophenotypes and Potential Medication Targetsmentioning

confidence: 99%

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Mathews

Richards

Niciu

et al. 2013

Translational Neuroscience

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Suicide and bipolar disorder (BD) are challenging, complex, and intertwined areas of study in contemporary psychiatry. Indeed, BD is associated with the highest lifetime risk for suicide attempt and completion of all the psychiatric conditions. Given that several clinical risk factors for both suicide and BD have been well noted in the literature, exploring the neurobiological aspects of suicide in BD may provide insights into both preventive measures and future novel treatments. This review synthesizes findings regarding the neurobiological aspects of suicide and, when applicable, their link to BD. Neurochemical findings, genes/epigenetics, and potential molecular targets for current or future treatments are discussed. The role of endophenotypes and related proximal and distal risk factors underlying suicidal behavior are also explored. Lastly, we discuss the manner in which preclinical work on aggression and impulsivity may provide additional insights for the future development of novel treatments.

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Section: Endophenotypes and Potential Medication Targetsmentioning

confidence: 99%

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Mathews

Richards

Niciu

et al. 2013

Translational Neuroscience

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“…The first modern use of lithium was for treatment of mania. 2 Lithium has also proven useful in major depression, particularly for augmentation of antidepressants; 9 for aggressive behaviour; 10,11 and it has a specific antisuicide effect. 12,13 Lithium’s prophylactic and antisuicidal effects are most unique – in these indications it is the most specific treatment in psychiatry.…”

Section: Introductionmentioning

confidence: 99%

Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics

2015

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After decades of research, the mechanism of action of lithium in preventing recurrences of bipolar disorder remains only partially understood. Lithium research is complicated by absence of suitable animal models of bipolar disorder and by having to rely on in vitro studies of peripheral tissues. A number of distinct hypotheses emerged over the years, but none has been conclusively supported or rejected. The common theme emerging from pharmacological and genetic studies is that lithium affects multiple steps in cellular signalling, usually enhancing basal and inhibiting stimulated activities. Some of the key nodes of these regulatory networks include GSK3, CREB, and Na+-K+ ATPase. Genetic and pharmacogenetic studies are starting to generate promising findings, but remain limited by small sample sizes. As full responders to lithium seem to represent a unique clinical population, there is inherent value and need for studies of lithium responders. Such studies will be an opportunity to uncover specific effects of lithium in those individuals who clearly benefit from the treatment.

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“…In previous reviews the use of anticonvulsants, beta blockers and atypical antipsychotic agents has been described in detail [20,31,40-49]. For more than 40 years, lithium has been used in many populations to treat violence [50]. Serotonin reuptake inhibitors are commonly used in the setting of depression but can also be effective for reducing chronic anger [20].…”

Section: Discussionmentioning

confidence: 99%

The physician's unique role in preventing violence: a neglected opportunity?

Umhau

Trandem²,

Shah

et al. 2012

BMC Med

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BackgroundEpisodes of explosive rage and violence comprise a symptom complex which can have a devastating effect on a person's life. In the community this behavior is seen as workplace violence, domestic abuse and road rage, while in the clinical setting, this behavior is rarely mentioned by patients, despite evidence that it can signify an important biological disorder that may afflict more than three percent of the population.DiscussionPatients are often reluctant to seek help for episodic attacks of rage, especially attacks which are accompanied by physical violence. Although, in the past, clinicians have had few treatment options to offer, recent neuroscience advances have created new possibilities to understand and help patients with this neglected problem. No formal medical guidelines for treating violence exist; however, many patients can be helped by diagnosis, referral and treatment. Treatment can include pharmaceuticals and nutrients, as well as referral for anger management or behavioral therapy.SummaryThe astute clinician has an opportunity to positively impact an important problem through the diagnosis and treatment of patients with symptoms of intermittent explosive disorder.

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The effect of lithium on impulsive aggressive behavior in man

Cited by 314 publications

References 11 publications

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics

The physician's unique role in preventing violence: a neglected opportunity?

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