The effect of lipids fromListeria monocytogenes on immune response in mice

Jakoniuk, P; Borowski, J; Szpak, Andrzej; Jarzyna, A

doi:10.1007/bf01946337

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…In a number of animal species, acquired cellular resistance plays a major role in recovery from a Listeria infection (9,16,18). A number of reports in the literature have also documented the adjuvant and mitogenic properties of Listeria extracts (6, 7) as well as of whole cells (12). Studies with two separate murine fibrosarcoma systems have shown the successful use of L. monocytogenes in tumor inhibition (3,28).…”

mentioning

confidence: 99%

Antitumor activity of Listeria monocytogenes on a guinea pig fibrosarcoma

Dustoor¹,

Fulton²,

Croft³

et al. 1979

Infect Immun

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Listeria monocytogenes-mediated tumor inhibition was studied in strain 13 guinea pigs by using a methylcholanthrene-induced fibrosarcoma (MCA-1). Mixtures of Listeria and tumor cells in ratios of 1:100, 1:200, or 1:400 (Listeria:MCA-1 cells) led to significant suppression of tumor growth. Intralesional injection of tumors on day 6 posttransplantation led to the regression of a highly significant number of tumors. Animals receiving injections of Listeria, either in a mixture with tumor cells or intralesionally, displayed enhanced skin test reactivity to a tumor extract. Tumor regressors were resistant for at least 2 to 3 months after the initial transplant to rechallenge with MCA-1 cells. Thus, with this particular tumor-host system, Listeria was successfully employed as an antitumor agent with no visibly detrimental side effects to the host.

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mentioning

confidence: 99%

Antitumor activity of Listeria monocytogenes on a guinea pig fibrosarcoma

Dustoor¹,

Fulton²,

Croft³

et al. 1979

Infect Immun

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show abstract

“…A monocytosisproducing extract of L. monocytogenes enhances the immune response to non-Listeria antigens (131,157,310). Other studies demonstrate that heat-killed Listeria (165), fluids from L. monocytogenes cultures (191), and cell wall-rich fractions of L. monocytogenes (61, 62; C. Schuffler and P. A. Campbell, Immunology, in press) enhance immune responses.…”

Section: Listeria Monocytogenesmentioning

confidence: 99%