The effect of lipid peroxides and superoxide dismutase on systemic lupus erythematosus: A preliminary study

Jiang, Xiaoxia; Chen, Fuwen

doi:10.1016/0090-1229(92)90091-2

Cited by 35 publications

(31 citation statements)

References 30 publications

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“…Consistent with previous studies (5,6), the 8-iso-PGF2α level was high while the GSH level was low in both cases of early-stage LN in this report, indicating the existence of oxidative stress in the early stage of LN.…”

Section: Discussionsupporting

confidence: 81%

“…As an inflammation of the kidney caused by systemic lupus erythematosus (SLE), LN has been documented to be closely associated with the imbalance between oxidative and antioxidative activities during the pathogenesis of LN (5,6). The few studies that have investigated the use of antioxidants in the treatment of LN have resulted in a satisfactory outcome (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

Gao

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The oxidative-antioxidative status is closely associated with the progression of systemic lupus erythematosus (SLE), and oxidative stress is customarily found in patients with SLE. N-acetylcysteine (NAC), a typical antioxidant, is reliable and often applied for clinical treatment. Lupus nephritis (LN) is a kidney disorder associated with SLE, but the treatment of LN with antioxidants is rarely documented. The present report describes two cases of early-stage LN that were orally treated with 1,200 mg NAC in addition to the standard therapy with hydroxychloroquine and calcitriol. Following the NAC administration, the glutathione level largely increased while the level of the lipid peroxidation biomarker 8-iso-prostaglandin F2α declined in both cases. In addition, the routine blood counts, 24-h urine protein, erythrocyte sedimentation rate and the SLE disease activity index were markedly improved. In conclusion, the present report of two cases has shown that NAC, as an antioxidant, may exert a beneficial effect to modulate the oxidative status in LN; however, the underlying mechanisms require further investigation. IntroductionSystemic lupus erythematosus (SLE), a chronic and multisystem autoimmune disorder that is characterized by dysregulated immune responses and production of pathogenic autoantibodies by immune cells such as B-cells, T-cells and dendritic cells (1). The clinical presentations of SLE include rash, oral ulcers, fatigue and arthralgias, and the course of the disease is unpredictable, with periods of flares alternating with remission (1). The pathogenesis of SLE remains unclear, and autoantibodies, proinflammatory and anti-inflammatory cytokines, lymphocyte subset abnormalities as well as genetic predispositions may contribute to the development of SLE (2). The disease occurs more often in women, with an incidence about nine times higher compared to men, and is also more common in non-Caucasian descent (1). SLE can affect the majority of organs and tissues such as skin, joints, lungs, blood vessels and kidneys. Lupus nephritis (LN) is a sever consequence of SLE, and ~ 40-70% of patients with SLE would develop LN (3).At present, LN is primarily treated with corticosteroids and immunosuppressive drugs, but is often associated with high morbidity and suboptimal outcomes (4). As an inflammation of the kidney caused by systemic lupus erythematosus (SLE), LN has been documented to be closely associated with the imbalance between oxidative and antioxidative activities during the pathogenesis of LN (5,6). The few studies that have investigated the use of antioxidants in the treatment of LN have resulted in a satisfactory outcome (7,8). N-acetylcysteine (NAC) is a typical antioxidant that is often used during clinical treatments (9). It is believed that NAC primarily acts as a glutathione precursor to minimize the hepatic risk caused by paracetamol poisoning (10). The present report describes two cases of early-stage LN that were treated with NAC. Case reportTwo female patients were diagnosed with ...

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

Gao

et al. 2015

Experimental and Therapeutic Medicine

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“…In fact, antioxidant enzyme activities are more abundant in erythrocytes where they play a crucial role in handling the ROS generated by activated neutrophils in the surrounding medium [19,20]. The significant increase in SOD activity may represent a compensatory response to ROS production which is known to augment SOD expression [10].…”

Section: Discussionmentioning

confidence: 98%

Lipid Peroxidation and Antioxidant System in the Tumor and in the Blood of Patients with Nasopharyngeal Carcinoma

Gargouri

Lassoued

Ayadi

et al. 2009

Biol Trace Elem Res

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Reactive oxygen species play a key role in cancer development by inducing and maintaining the oncogenic phenotypes of cancer cells. In this study, we examined lipid peroxidation and antioxidant enzymes activities in the blood and in the tumor of nasopharyngeal carcinoma patients. Plasma malondialdehyde, conjugated dienes, erythrocytes catalase, and superoxide dismutase activities have been measured in 30 untreated nasopharyngeal carcinoma patients and 30 controls on one hand. On the other hand, tumor malondialdehyde level, catalase, and superoxide dismutase activities have been measured in five nasopharyngeal carcinoma patients and compared with four controls. The lipid peroxidation was confirmed in the plasma by the high levels of malondialdehyde and conjugated dienes (p<0.001, respectively). Additionally, significantly higher concentrations of malondialdehyde were found in biopsies compared to the control group (p<0.001). In erythrocytes, superoxide dismutase activity was higher in patients than in controls (p<0.05), while it was unchanged in the tumor (p>0.05). Both erythrocytes and tumor catalase activities were significantly lower in patients than in controls (p<0.001, respectively). Statistical studies have shown a positive correlation between malondialdehyde level and IgA antibodies level against Epstein–Barr virus capsid antigen (p<0.05). In conclusion, we reported the presence of an oxidative stress in the blood and in the biopsies of nasopharyngeal carcinoma patients where Epstein–Barr virus seems to play a role.

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“…The SOD activity was determined by spectrophotometry (420 nm) using the pyrogallol assay as described previously (Jiang and Chen 1992) and modified as follows: the rate of autoxidation of pyrogallol (Sigma-Aldrich) in Tris-cacodylic acid (Sigma-Aldrich) diethylenetriaminepentaacetic acid (DTPA) (Sigma-Aldrich) buffer (pH 8-8.2) was determined (A1). The autoxidation of pyrogallol was evaluated under the same conditions after addition of 25 lL of extract (A2).…”

Section: Determination Of Sod Activitymentioning

confidence: 99%

Phenolic contents and antioxidant activity of ethanolic extract of Capparis spinosa

et al. 2014

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Caper plant (Capparis spinosa) extracts have been associated with diverse biological activities including anti-oxidant properties. In this work, we characterized the hydro-ethanolic extract obtained from C. spinosa leaves [hydroethanolic extract of C. spinosa (HECS)] by analyzing the content in antioxidant compounds such as polyphenols, flavonoids and anthocyanins. Further, we evaluated HECS antioxidant activities in vitro using bleaching of 1,1-diphenyl-2-picrylhydrazyl radical and ABTS test as well as by pretreatment of HeLa cells exposed to Fe

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The effect of lipid peroxides and superoxide dismutase on systemic lupus erythematosus: A preliminary study

Cited by 35 publications

References 30 publications

Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

Lipid Peroxidation and Antioxidant System in the Tumor and in the Blood of Patients with Nasopharyngeal Carcinoma

Phenolic contents and antioxidant activity of ethanolic extract of Capparis spinosa

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