The Effect of Limited Perioperative Nonsteroidal Anti-inflammatory Drugs on Patients Undergoing Anterior Cruciate Ligament Reconstruction

Soreide, Endre; Granan, Lars-Petter; Hjorthaug, Geir Aasmund; Dimmen, Sigbjørn; Nordsletten, Lars

doi:10.1177/0363546516657539

Cited by 27 publications

(35 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The risk of revision was not influenced by the administration of non-steroidal anti-inflammatory drugs (NSAIDs). However, a subgroup of patients undergoing ACL reconstruction with patella tendon autograft showed a decreased risk of revision when NSAIDs were administered (HR 0.3 [95% CI 0.1 to 0.8], p=0.016) 18. In addition, the side of primary injury (right or left) was not associated with additional ACL reconstruction,15 and smoking or smokeless tobacco did not influence the 2-year risk of revision ACL reconstruction 12…”

Section: Resultsmentioning

confidence: 99%

Factors associated with additional anterior cruciate ligament reconstruction and register comparison: a systematic review on the Scandinavian knee ligament registers

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Factors associated with additional anterior cruciate ligament reconstruction and register comparison: a systematic review on the Scandinavian knee ligament registers

et al. 2018

View full text Add to dashboard Cite

show abstract

“…34 However, commonly used anesthetics and NSAIDs such as bupivacaine and ketorolac tromethamine that reduce pain from tendinopathy are believed to exhibit cytotoxicity toward tenocytes and affect tendon healing. 35,36 Therefore, there is extensive concern regarding this therapeutic modality and a need to achieve balance between pain reduction and decreased cytotoxicity. Ascorbic acid has been shown to improve the rate and quality of rat Achilles tendon repair.…”

Section: Discussionmentioning

confidence: 99%

Real-Time Monitoring of Ascorbic Acid-Mediated Reduction of Cytotoxic Effects of Analgesics and NSAIDs on Tenocytes Proliferation

Chiu

Chen

et al. 2019

Dose-Response

View full text Add to dashboard Cite

Tendinopathy is a common painful musculoskeletal disorder treated by injection of analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs), which are believed to have cytotoxicity toward tenocytes. Ascorbic acid is an antioxidant that promotes collagen biosynthesis and prevents free radical formation. It is believed to protect tenocytes from oxidative stress. The optimal concentration of ascorbic acid, especially when used in conjunction with anesthetics and NSAIDs injection, to treat different stages of tendinopathies is unknown. Human tenocytes were isolated from a torn edge of the supraspinatus tendon of a 51-year-old male patient during arthroscopic repair. We monitored real-time changes in human tenocyte proliferation upon exposure to different concentrations of ascorbic acid, bupivacaine, and ketorolac tromethamine using the xCELLigence system. No significant changes in cell index were observed between the control group and tenocytes treated with the 3 concentrations of ascorbic acid. Tenocytes exposed to 0.5% bupivacaine and 30 or 15 mg/mL ketorolac tromethamine revealed significant reduction in tenocytes proliferation. Bupivacaine 0.5% with 250 μg/mL ascorbic acid and 15 mg/mL ketorolac tromethamine with 250 μg/mL ascorbic acid showed the least cytotoxicity against tenocytes. The optimal ascorbic acid concentration required to reduce the cytotoxic effects of bupivacaine and ketorolac tromethamine was demonstrated using this platform.

show abstract

“…It is well established that NSAIDs is applied in modern multimodal pain therapy [ 26 ]. In addition, NSAIDs are commonly reported to prevent those common adverse side effects of opioids, including sweating, dizziness, nausea, vomiting, loss of appetite and dysuria [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Do Nonsteroidal Anti-Inflammatory Drugs Affect Tissue Healing After Arthroscopic Anterior Cruciate Ligament Reconstruction?

Liu

Shrestha³

et al. 2018

Med Sci Monit

View full text Add to dashboard Cite

BackgroundExperimental studies have reported nonsteroidal anti-inflammatory drugs (NSAIDs) could impair tendon healing. The purpose of this study was to investigate whether NSAIDs could affect recovery of knee joint function in patients after anterior cruciate ligament (ACL) reconstruction.Material/MethodsWe enrolled 40 patients treated with celecoxib and 40 patients treated with tramadol, who underwent ACL reconstruction from January 2011 to December 2017. Visual analogue scale (VAS) and functional outcomes were collected and evaluated. The follow-up period was 12 months.ResultsIn both groups, all patients obtained pain release after surgery, compared with that before surgery. But no significant differences were observed between the 2 groups in VAS scores. We also did not find any differences between the 2 groups at 1 year of follow-up, in terms of anterior drawer test, Lachman test, side-to-side laxity assessed by KT-2000, IKDC score, Lysholm score, and Tegner scale. However, the celecoxib group showed a reduced incidence of nausea compared to the tramadol group (P=0.048).ConclusionsThe use of NSAIDs after ACL reconstruction is relatively safe and could decrease adverse side effects which were caused by opioid drugs.

show abstract

The Effect of Limited Perioperative Nonsteroidal Anti-inflammatory Drugs on Patients Undergoing Anterior Cruciate Ligament Reconstruction

Cited by 27 publications

References 167 publications

Factors associated with additional anterior cruciate ligament reconstruction and register comparison: a systematic review on the Scandinavian knee ligament registers

Factors associated with additional anterior cruciate ligament reconstruction and register comparison: a systematic review on the Scandinavian knee ligament registers

Real-Time Monitoring of Ascorbic Acid-Mediated Reduction of Cytotoxic Effects of Analgesics and NSAIDs on Tenocytes Proliferation

Do Nonsteroidal Anti-Inflammatory Drugs Affect Tissue Healing After Arthroscopic Anterior Cruciate Ligament Reconstruction?

Contact Info

Product

Resources

About