The effect of light scattering on multifocal electroretinography

Chan, Ho Lung Henry; Siu, Aw W.; Yap, Maurice; Brown, Brian

doi:10.1046/j.1475-1313.2002.00052.x

Cited by 16 publications

(17 citation statements)

References 31 publications

(41 reference statements)

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“…315 Besides assessing the mfERG changes in cataract patients, studies using artificial light scattering have also been performed to mimic the effects of cataract on mfERG. 8,31,296 Similar to the findings in cataract patients, experimental light scattering resulted in reduction in mfERG responses particularly in the central retina. 8,31,296 Chan et al showed that the peripheral mfERG response amplitude densities may also increase due to light scattering.…”

Section: Influence Of Cataract On Mfergsupporting

confidence: 72%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

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Section: Influence Of Cataract On Mfergsupporting

confidence: 72%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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“…However, in our study, we found that central retinal responses were decreased but peripheral retinal responses were not. This finding is slightly different from the report by Chan et al 14 They found that central mfERG responses were reduced, but peripheral retinal responses were increased under light-scattering conditions. It is not clear why peripheral retinal responses were not affected by cataract in our study, but we can conclude generally that light-scattering caused by media opacities can affect the amplitude of mfERG responses.…”

Section: Cataract and Mferg W-k Tam Et Al 693contrasting

confidence: 99%

“…It is not clear why peripheral retinal responses were not affected by cataract in our study, but we can conclude generally that light-scattering caused by media opacities can affect the amplitude of mfERG responses. 11,14 There have been several studies on the effect of aging on mfERG topography. [28][29][30][31][32] Mohidin et al 29 found that the decrease in response density in aged eyes was mainly at the central 101 diameter of the macular with no significant reduction in peripheral responses.…”

Section: Cataract and Mferg W-k Tam Et Al 693mentioning

confidence: 99%

“…12 By using acrylic sheets or liquid-crystaldiffusers, the light-scattering effects of cataract have been simulated in mfERG studies. 13,14 In a study on two subjects, Arai et al 13 showed that central mfERG responses decreased slightly with increased scattering level, but that the peripheral responses did not show a corresponding reduction. Our own study on a larger group of young subjects showed that the central mfERG responses decreased significantly with increasing light scattering, but paradoxically the peripheral responses increased with increasing light scattering.…”

Section: Introductionmentioning

confidence: 99%

“…Our own study on a larger group of young subjects showed that the central mfERG responses decreased significantly with increasing light scattering, but paradoxically the peripheral responses increased with increasing light scattering. 14 In this study, we wanted to find out how cataract affects the mfERG.…”

Section: Introductionmentioning

confidence: 99%

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Effects of different degrees of cataract on the multifocal electroretinogram

Tam

Chan

Brown

et al. 2004

Eye

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Aim To study the effect of different degrees of nuclear cataract on the multifocal electroretinogram (mfERG). Methods mfERGs were recorded from 30 elderly subjects with very mild, mild, or moderate nuclear cataracts using a VERIS System (version 4.1). The subjects were divided into three groups (10 in each group) according to their degree of nuclear cataracts as classified according to the Lens Opacities Classification System III (LOCS III). No subjects had any significant eye disease or degenerative changes except for cataracts. The mfERG responses were grouped into six concentric rings for analysis. Both the N1 and P1 amplitudes and the latencies of N1 and P1 of first-order responses were used for analysis. Results Amplitudes of N1 and P1 from the central retina (141) were significantly reduced in patients with mild or moderate cataract when compared with subjects with very mild cataract. However, there was no significant reduction of N1 and P1 amplitudes in the paracentral retina (14-401). There was no difference in the latencies of N1 and P1 in these three groups of subjects. Conclusions The mfERG responses from the central retina (central 141) were affected by the severity of cataract, but responses from the paracentral retina (14-401) were not affected. This suggests that in interpreting the mfERG in subjects with mild or moderate cataract subjects some care should be taken as reduced amplitudes (N1 and P1) will be expected from the central retina.

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