The effect of lidocaine on PpIX photobleaching and outcome of ALA-PDT in vitro

Mikolajewska, Patrycja; Juzeniene, Asta; Moan, Johan Emelian

doi:10.1016/j.pdpdt.2007.10.002

Cited by 6 publications

(2 citation statements)

References 89 publications

(72 reference statements)

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“…Patients with PI-NRS ≥7 were given lidocaine, which becomes active 5 min after injection. The application of local lidocaine injection might interrupt PDT for a few minutes, but it has no influence on PpIX photobleaching and ALA-PDT outcome (21).…”

Section: Discussionmentioning

confidence: 99%

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus

Shi¹,

Miao²,

Zhang³

et al. 2016

Acta Derm Venerol

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The aim of this study was to evaluate the effectiveness of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of vulvar lichen sclerosus (VLS) and compare its effectiveness with that of clobetasol propionate. Four sessions of topical photodynamic therapy (PDT) were administered at 2-week intervals (n = 20). Clobetasol propionate (0.05%) was used daily for 8 weeks (n = 20). The rate of complete response in the PDT group (14/20) was double that of the clobetasol propionate group (7/20) (p < 0.05, 2 = 4.912). Horizontal visual analogue scores indicated that PDT was more effective than clobetasol propionate. Pain intensity numeric rating scale values for PDT were between 3.05 and 4.45. One month after the final session of PDT, only one patient relapsed and all 7 patients in clobetasol propionate group relapsed. ALA-PDT is a well-tolerated and effective option for the treatment of VLS.

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Section: Discussionmentioning

confidence: 99%

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus

Shi¹,

Miao²,

Zhang³

et al. 2016

Acta Derm Venerol

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“…Photosensitizer photobleaching and the fluorescence monitoring of photoproducts have become a highly focused area of research within PDT dosimetry in recent years [5][6][7][8]. It has been demonstrated that photobleaching can be used to monitor the processes of Photodynamic Therapy: the dose of singlet oxygen can be well predicted by the dosimetric photobleaching kinetics of photosensitizer in a photosensitizing system [9][10][11]. Furthermore, photosensitizer photobleaching provided a reliable method to estimate the inactivation efficacy of singlet oxygen on target tissues during treatment comprehensively, it is therefore inextricably linked with the effectiveness of PDT [12,13].…”

Section: Introductionmentioning

confidence: 99%

Protoporphyrin IX photobleaching of subcellular distributed sites of leukemic HL60 cells based on ALA-PDT <i>in vitro</i>

Huang¹,

Chen²,

Lv³

et al. 2012

JBiSE

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The leukaemia cells HL60, incubated in 10 mM/ml ALA (5-aminolevulinic) for 4 hours, were carried an experimental research with fluorescent probes in photodynamic therapy (PDT) based on ALA by using PDT reaction room (The average fluence rate of the 412 nm source was 5 mW/cm<sup>2</sup>). Cells viability were determined using a Cell Counting Kit-8 (CCK-8) assay, and PpIX Photobleaching of subcellular distributed sites of HL60 cells in vitro were investigated by fluorescence spectra acquired during treatment. The results showed that the fluorescence intensity of mitochondria, lysosomes, endoplasmic reticulum had decreased by 81.5%, 52.3% and 21.0%, respectively, compared with their initial values after a 45-minute light treatment. The rate of PpIX photobleaching in mitochondria was significantly higher than others. Addi-tionally, the change of the activity of HL60 cells was basically characterized by the change fluorescence intensity in mitochondria, which suggest that mitochondria is one of main therapeutic targets of photodynamic therapy

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Morphological characterization of amidinophenylporphyrins interacting with DNA by photo irradiation

Wang

Song

Zheng

et al. 2013

Chinese Chemical Letters

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The effect of lidocaine on PpIX photobleaching and outcome of ALA-PDT in vitro

Abstract: Lidocaine had no significant influence on PpIX photobleaching and ALA-PDT outcome in vitro.

Cited by 6 publications

References 89 publications

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus

Protoporphyrin IX photobleaching of subcellular distributed sites of leukemic HL60 cells based on ALA-PDT <i>in vitro</i>

Morphological characterization of amidinophenylporphyrins interacting with DNA by photo irradiation

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The effect of lidocaine on PpIX photobleaching and outcome of ALA-PDT in vitro

Abstract: Lidocaine had no significant influence on PpIX photobleaching and ALA-PDT outcome in vitro.

Cited by 6 publications

References 89 publications

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus

Comparison of 5-Aminolevulinic Acid Photodynamic Therapy and Clobetasol Propionate in Treatment of Vulvar Lichen Sclerosus

Protoporphyrin IX photobleaching of subcellular distributed sites of leukemic HL60 cells based on ALA-PDT &lt;i&gt;in vitro&lt;/i&gt;

Morphological characterization of amidinophenylporphyrins interacting with DNA by photo irradiation

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Protoporphyrin IX photobleaching of subcellular distributed sites of leukemic HL60 cells based on ALA-PDT <i>in vitro</i>