The effect of lidocaine on in vitro adhesion and migration of equine neutrophils

Cook, Vanessa L.; Neuder, Laura E.; Blikslager, Anthony T.; Jones, Samuel L.

doi:10.1016/j.vetimm.2008.12.017

Cited by 37 publications

(28 citation statements)

References 18 publications

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“…Importantly, this increase in laminar E‐selectin mRNA concentration in the LD group implies that the systemic administration of lidocaine has an inflammatory/activating effect on the endothelium. This in vivo finding is corroborated by a recent report in which ex vivo exposure of equine neutrophils to lidocaine did not inhibit neutrophil migration or adhesion at a therapeutic concentration, and actually increased neutrophil adhesion and transendothelial migration at higher concentrations of lidocaine (Cook et al. 2009b).…”

Section: Discussionsupporting

confidence: 80%

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Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis

Williams¹,

Lin²,

Loftus³

et al. 2010

Equine Veterinary Journal

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SummaryReasons for performing study: Laminitis is a serious complication of horses suffering from sepsis/endotoxaemiarelated events. Laminitis in horses and organ injury in human sepsis are both reported to involve inflammatory injury to the laminae/organs including early activation of endothelium and leucocytes leading to emigration of neutrophils into the tissue interstitium. In the black walnut extract (

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Section: Discussionsupporting

confidence: 80%

“…Lidocaine is an acidic local anaesthetic (Catterall and Mackie 2005), which could possibly be an irritant to cells due to its pH. However, the acidity of lidocaine was determined to not be a factor in its role as an initiator of inflammation in the in vitro study (Cook et al. 2009b).…”

Section: Discussionmentioning

confidence: 99%

Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis

Williams¹,

Lin²,

Loftus³

et al. 2010

Equine Veterinary Journal

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“…In fact, IV lidocaine actually may promote inflammation by upregulation of equine endothelial adhesion molecules . Furthermore, supraphysiologic concentrations of lidocaine promote equine neutrophil migration in vitro, although this occurred at a concentration more than 500 times higher than the plasma concentrations detected in the present study . These results indicate that not all mammalian neutrophils behave similarly in response to lidocaine.…”

Section: Discussioncontrasting

confidence: 71%

The Effect of Intravenous Lidocaine Infusion on Bronchoalveolar Lavage Cytology in Equine Recurrent Airway Obstruction

Wilson

Berney

Behan

et al. 2012

Veterinary Internal Medicne

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Background: Lidocaine decreases neutrophilic inflammation in models of acute lung injury and decreases inflammation in asthmatic patients. Neutrophilic bronchiolitis develops in recurrent airway obstruction (RAO), but it remains unknown if lidocaine infusion decreases neutrophil migration into the airways.Hypothesis: Lidocaine decreases neutrophilic inflammation as measured in BALF in RAO-affected horses. Animals: Six RAO-susceptible horses in remission. Methods: In a randomized cross-over design, horses received lactated Ringer's solution (LRS) IV or lidocaine hydrochloride IV with a minimum of 4 weeks at pasture between treatments. Treatments were delivered as continuous infusions beginning 4 hours before and for 68 hours during exposure to hay and straw challenge. Clinical score (CS, grade 0-8), maximal change in pleural pressure (ΔPpl max ), and bronchoalveolar lavage fluid (BALF) cytology were measured at baseline and the end of challenge (day 4). Plasma lidocaine concentrations were monitored daily.Results: At baseline, there were no significant differences in variables between treatments. Plasma lidocaine concentration was consistently > 1100 ng/mL. After challenge, CS increased significantly [baseline: 2/8 (2-3), [median (interquartile range)]; day 4: 4/8 (4-5) P = .0006] as did ΔPpl max [baseline: 3.6 (2.63-4.95) cmH 2 0; day 4: 9.62 (6.5-16) P = .0036], but there was no difference between treatments. Percentage of neutrophils was not different between treatments, but lidocaine infusion significantly increased BALF total cells [baseline: LRS 2.18 ± 0.82 9 10 5 cells/mL (mean ± SD), lidocaine 1.6 ± 0.3 9 10

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“…While lidocaine has always been labelled as a prokinetic drug in the context of POI treatment, any affect may be mediated via its analgesic and/or antiinflammatory properties [153][154][155], Lidocaine, and other local anaesthetics, inhibit several functions of neutrophils, such as adhesion and phagocytosis [154]. Conversely, the same group, using an in vitro model, reported an increase in neutrophilic migration in response to lidocaine [156]. Conversely, the same group, using an in vitro model, reported an increase in neutrophilic migration in response to lidocaine [156].…”

Section: Prokineticsmentioning

confidence: 99%

An update on equine post‐operative ileus: Definitions, pathophysiology and management

Lisowski

Pirie

Blikslager

et al. 2018

Equine Veterinary Journal

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Post-operative ileus (POI) is a serious condition which any horse undergoing abdominal surgery is at risk of developing, leading to increased hospitalisation time and resulting costs. Advances in the understanding of the development of equine POI are mainly based on human and rodent literature, where manipulation-induced inflammation has been identified as a trigger, with activation of resident muscularis externa macrophages playing a crucial role in the pathophysiology. Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence.

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The effect of lidocaine on in vitro adhesion and migration of equine neutrophils

Cited by 37 publications

References 18 publications

Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis

Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis

The Effect of Intravenous Lidocaine Infusion on Bronchoalveolar Lavage Cytology in Equine Recurrent Airway Obstruction

An update on equine post‐operative ileus: Definitions, pathophysiology and management

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