The Effect of Levodopa on Pulmonary Function in Parkinson's Disease: A Systematic Review and Meta-Analysis

Monteiro, Larissa; Souza‐Machado, Adelmir; Valderramas, Sílvia; Melo, Aílton

doi:10.1016/j.clinthera.2012.03.001

Cited by 63 publications

(62 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were 101 patients classified as mild and 77 classified as moderate/severe according to the revised Hoehn-Yahr scale (12,17). The average delay from the initial symptom to mild PD (stages 1−2) was 52.74±45.64 months.…”

Section: Resultsmentioning

confidence: 99%

Clinical profile of Parkinson's disease in the Gumei community of Minhang district, Shanghai

Liu¹,

Gu²,

Dong³

et al. 2014

Clinics

View full text Add to dashboard Cite

OBJECTIVE:We examined the demographic and clinical profiles of Parkinson's disease in Shanghai, China, to assist in disease management and provide comparative data on Parkinson's disease prevalence, phenotype, and progression among different regions and ethnic groups.METHODS:A door-to-door survey and follow-up clinical examinations identified 180 community-dwelling Han-Chinese Parkinson's disease patients (104 males, 76 females).RESULTS:The average age at onset was 65.16±9.60 years. The most common initial symptom was tremor (112 patients, 62.22%), followed by rigidity (38, 21.11%), bradykinesia (28, 15.56%) and tremor plus rigidity (2, 1.11%). Tremor as the initial symptom usually began in a single limb (83.04% of patients). The average duration from onset to mild Parkinson's disease (Hoehn-Yahr phase 1–2) was 52.74±45.64 months. Progression from mild to moderate/severe Parkinson's disease (phase≥3) was significantly slower (87.07±58.72 months; p<0.001), except for patients presenting initially with bradykinesia (53.83±24.49 months). Most patients (149/180, 82.78%) took levodopa with or without other drugs. The Hamilton Anxiety Scale revealed symptoms of clinical anxiety in 35 patients, and the Hamilton Depression Scale revealed depressive symptoms in 88 patients. The depressed or anxious subgroup (123 patients) demonstrated a significantly younger age at onset (55.54±7.68 years) compared with the overall mean (p<0.05).CONCLUSION:Unilateral limb tremor was the most common initial symptom, and motor function deteriorated slowly over ≈4−9 years. Earlier-onset patients experience greater psychiatric dysfunction.

show abstract

Section: Resultsmentioning

confidence: 99%

Clinical profile of Parkinson's disease in the Gumei community of Minhang district, Shanghai

Liu¹,

Gu²,

Dong³

et al. 2014

Clinics

View full text Add to dashboard Cite

show abstract

“…Because patients with PD have been reported to have both obstructive and restrictive pulmonary dysfunction[263,264] as well as abnormal response to hypercapnia[265], researchers have hypothesized that sleep apnea risk is increased in PD relative to the general population. However, controlled studies on sleep apnea in PD over the last 10 years consistently failed to demonstrate any increased risk for sleep apnea.…”

Section: Sleep Related Breathing Disordersmentioning

confidence: 99%

“…As discussed previously, pulmonary dysfunction has been proposed as a potential risk for SDB in PD patients[263,264]. In individual patients, SDB could be related to rigidity of muscles of the chest wall, restricted lung volumes secondary to changes in posture/kyphoscoliosis, or altered flow volume loop due to 4-8Hz oscillations in upper airway muscles[274,275].…”

Section: Sleep Related Breathing Disordersmentioning

confidence: 99%

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

248

228

View full text Add to dashboard Cite

Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

show abstract

“…Minimizing the interruption of oral anti-Parkinsonism medication during the perioperative period could help to improve respiratory function. 32 Urinary tract infection—another infectious complication—can be attributed to PD-related bladder dysfunction that can cause multiple urinary symptoms including urgency, frequency, nocturia, and urinary retention. 33 Frequent bladder scans to check for retention and higher vigilance in monitoring for urinary infection may be useful to avoid urinary tract infection and treat it as promptly as possible.…”

Section: Discussionmentioning

confidence: 99%

Outcomes After Non-neurological Surgery in Patients With Parkinson's Disease

et al. 2016

View full text Add to dashboard Cite

Patients with Parkinson disease (PD) were known to have increased risk of complications during hospitalization. The purpose of this study is to validate the global features of postoperative adverse outcomes for patients with PD.Using reimbursement claims from Taiwan's National Health Insurance Research Database, we conducted a nationwide retrospective cohort study of 6455 patients with preoperative PD receiving major surgery during 2008 to 2012. With a propensity score matching procedure, 12,910 surgical patients without PD were selected for comparison. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for 9 major postoperative complications and 30-day postoperative mortality associated with preoperative PD were calculated in the multivariate logistic regressions.Patients with PD had increased risk of postoperative pulmonary embolism (OR 2.72, 95% CI 1.45–5.10), stroke (OR 1.77, 95% CI 1.53–2.05), pneumonia (OR 1.98, 95% CI 1.70–2.31), urinary tract infection (OR 1.52, 95% CI 1.35–1.70), septicemia (OR 1.54, 95% CI 1.37–1.73), acute renal failure (OR 1.36, 95% CI 1.07–1.73), and mortality (OR 1.45, 95% CI 1.06–1.98). The association between preoperative PD and postoperative adverse events was significant in both sexes and every age group. Low income, ≥65 years of age, surgery not in medical center, highest quartile of PD medication users, and more medical conditions worsen the risk of postoperative adverse events in patients with PD.This study showed increased postoperative complications and mortality in patients with PD. Our findings suggest that revision of postoperative care protocols for this population is urgently needed.

show abstract

The Effect of Levodopa on Pulmonary Function in Parkinson's Disease: A Systematic Review and Meta-Analysis

Cited by 63 publications

References 20 publications

Clinical profile of Parkinson's disease in the Gumei community of Minhang district, Shanghai

Clinical profile of Parkinson's disease in the Gumei community of Minhang district, Shanghai

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Outcomes After Non-neurological Surgery in Patients With Parkinson's Disease

Contact Info

Product

Resources

About