Cross sections for production of a broad variety of high-spin isomers, i.e., 177 Hf m2 ͑37/2 − ͒, 179 Hf m2 ͑25/2 − ͒, 177 Lu m ͑23/2 − ͒, 180 Hf m ͑8 − ͒, and 178 Ta m ͑7 − ͒ from 181 Ta targets irradiated with 100, 145, 200, 350, and 500 MeV protons have been measured by off-line ␥-spectroscopy. A radiochemical procedure was used to achieve high sensitivity. Isomer ratios in products ranging down to 10 −3 were based on experimentally measured and theoretically calculated cross sections. It was demonstrated that the isomer ratio does not depend essentially on proton energy in the given range. Regularities in formation of isomeric states in different nuclear reactions are discussed.