The effect of lens edge design versus anterior capsule overlap on posterior capsule opacification

Smith, Stacy; Daynes, Todd; Hinckley, Michael; Wallin, Trevin; Olson, Randall J.

doi:10.1016/j.ajo.2004.04.028

Cited by 64 publications

(33 citation statements)

References 26 publications

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“…There is supporting evidence in literature that the incidence and severity of PCO is strongly affected by, and may be proportional to, the degree of anterior capsule overlap on the IOL. 9-12, 34,35 The results obtained by placing the edge of the anterior capsule completely over the IOL optic suggest that the lens implant, which is sequestered in the capsular bag, is pushed in a posterior direction due to pressure from the anterior capsule. This force may lead to greater contact between the IOL and the M A N U S C R I P T…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 95%

The Effect of Single-Piece Hydrophobic Acrylic Intraocular Lenses on the Development of Posterior Capsule Opacification

Praveen

Shah

Vasavada

et al. 2015

American Journal of Ophthalmology

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 95%

The Effect of Single-Piece Hydrophobic Acrylic Intraocular Lenses on the Development of Posterior Capsule Opacification

Praveen

Shah

Vasavada

et al. 2015

American Journal of Ophthalmology

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“…In all cases, the rhexis sat completely on the IOL, which clinically is linked to reduced PCO rates. 25 Moreover, the capsular bag is inverted to allow greater interaction between the IOL and the adjacent capsule. Therefore, the lenses are tested with the highest likelihood of success.…”

Section: Discussionmentioning

confidence: 99%

A Fully Human In Vitro Capsular Bag Model to Permit Intraocular Lens Evaluation

Dawes

Illingworth

Wormstone

2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To establish a fully human in vitro culture model with which to test the putative effects of intraocular lens (IOL) designs in preventing posterior capsule opacification (PCO) after cataract surgery. METHODS. A sham cataract operation was performed to prepare human capsular bags from donor lenses. In one capsular bag of a donor pair, an intraocular lens (PMMA round-edge IOL or acrylic IOL) was implanted while the other capsular bag remained aphakic. Bags were transferred to a Petri dish and secured anterior-face down using entomological pins. Capsular bags were maintained in Eagle's minimum essential medium supplemented with 2% human serum and 10 ng/mL TGF-␤ to drive growth and matrix contraction. RESULTS. In the absence of an IOL, cells appeared within the central posterior capsule at 4.38 Ϯ 0.26 days, whereas in the presence of a PMMA round-edge IOL or an acrylic IOL they appeared at 8 Ϯ 0.41 days and 11 Ϯ 0.7 days, respectively. Immunocytochemical analysis showed an accumulation of cells at the edge of the acrylic IOL and a less evident accumulation with the PMMA round-edge IOL. Moreover, matrix contraction was more prominent in the absence of an IOL but was still apparent, to a lesser degree, in the presence of a PMMA round-edge IOL. The acrylic IOL greatly suppressed matrix contraction. CONCLUSIONS. The authors have developed a fully human in vitro capsular bag system that relates well to clinical observations and permits the testing of novel intraocular lenses. (Invest Ophthalmol Vis Sci. 2012;53:23-29)

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“…A considerable volume of clinical research shows that a square IOL edge inhibits lens epithelial cell migration to the posterior capsule. [17][18][19] In the event of the development of postoperative posterior capsular opacification, the treatment is a capsulotomy using an …”

Section: Posterior Capsular Opacificationmentioning

confidence: 99%

Complications of cataract surgery

Chan

Mahroo

Spalton

2010

Clinical and Experimental Optometry

131

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Modern cataract surgery is safe in more than 95 per cent of patients. In the small number of cases where a serious complication occurs, the most common is an intra-operative posterior capsular rupture. This can lead to vitreous loss or a dropped nucleus and can increase the risk of post-operative cystoid macular oedema or retinal detachment. Postoperatively, posterior capsular opacification is the most common complication and can be readily treated with a YAG capsulotomy. The most devastating complication is endophthalmitis, the rate of which is now significantly decreased through the use of intracameral antibiotics. As a clinician, the most important step is to assess the patient pre-operatively to predict higher risk individuals and to counsel them appropriately. In these patients, various pre-or intra-operative management steps can be taken in addition to routine phacoemulsification to optimise their visual outcome.

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The effect of lens edge design versus anterior capsule overlap on posterior capsule opacification

Cited by 64 publications

References 26 publications

The Effect of Single-Piece Hydrophobic Acrylic Intraocular Lenses on the Development of Posterior Capsule Opacification

The Effect of Single-Piece Hydrophobic Acrylic Intraocular Lenses on the Development of Posterior Capsule Opacification

A Fully Human In Vitro Capsular Bag Model to Permit Intraocular Lens Evaluation

Complications of cataract surgery

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