The effect of legislation on outcomes of assisted reproduction technology: lessons from the 2004 Italian law

Sala, Giovanni Battista La; Villani, Maria Teresa; Nicoli, Alessia; Valli, Barbara; Iannotti, Fausto; Blickstein, Isaac

doi:10.1016/j.fertnstert.2007.04.051

Cited by 20 publications

(19 citation statements)

References 18 publications

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“…In the present study we assessed the clinical outcome of a larger number of HA-ICSI treatments. In accordance with IVF law in Italy at the time of the study, the ICSI treatments were performed on a limited number of oocytes per patient (between 1 and 3) with the obligation to re-implant all available embryos [6]. Confirming the observation of our previous study, we found a trend towards better fertilization and pregnancy in the study group (Physiologic HA-ICSI; Table 1).…”

Section: Discussionsupporting

confidence: 84%

“…After decumulation and quality evaluation, the three best available MII oocytes were inseminated by ICSI, according to the Italian law regulating Assisted Reproductive Technology, at the time of this study [6].…”

Section: Controlled Ovarian Stimulation and Oocyte Selectionmentioning

confidence: 99%

“…Furthermore, these HA-bound spermatozoa show low chromosomal aneuploidies and DNA fragmentation, and good nuclear morphology [4,5]. Thus, HA-sperm selection prior to intracytoplasmic sperm injection (ICSI) helps to optimize the outcome of the treatment, especially when insemination of only a limited number of oocytes is allowed by law [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficiency of hyaluronic acid (HA) sperm selection

Parmegiani

Cognigni

Ciampaglia

et al. 2009

J Assist Reprod Genet

116

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Section: Discussionsupporting

confidence: 84%

Section: Controlled Ovarian Stimulation and Oocyte Selectionmentioning

confidence: 99%

See 1 more Smart Citation

Efficiency of hyaluronic acid (HA) sperm selection

Parmegiani

Cognigni

Ciampaglia

et al. 2009

J Assist Reprod Genet

116

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“…However other studies showed, in contrast to ours and other authors publications, that the new legislation neither reduced success rates of assisted reproductive technologies (ART) using fresh embryos, nor increased the multiple birth rate [9,10]. Moreover La Sala et al [12].…”

Section: Incontrasting

confidence: 63%

The Italian Experience of A Restrictive IVF Law: A Review

Setti¹,

Patrizio²

2012

J Fertiliz In Vitro

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In March 2004 the Italian Parliament enacted a Law (Law 40/2004) establishing a long list of restrictions for ART procedures. The law articles were constructed around the assumption of considering the embryo as a human being, with the same or even more rights of the woman or the couple seeking treatment for their infertility-related childless. In detail, the Law obliged to use only 3 oocytes to be fertilised and all the resulting embryos had to be transferred. Embryo freezing as well as pre implantation screening (PGS) or diagnosis (PGD) and sperm or oocytes donation were forbidden. In May 2009 the Italian Constitutional Court was called to judge parts of the Law 40 and cancelled some of the restrictions since they violated women's rights to have access to the best possible treatment with the lower health risks for both her and the future children. The Constitutional Court stated that the decision on the number of oocytes to be used for insemination, the embryos to be transferred and the embryos to be frozen were a matter of good clinical practice and under the full responsibility of the reproductive specialist. PGD and PGS remains a matter of debate because the Court was not called specifically to address this subject, although a clear opinion in favour has been expressed in previous decisions. The Constitutional Court will be called only in the future to express a judgement on gametes donation that is still forbidden. The present work reviews the clinical and social effects produced by 5 years of a restrictive ART Law (2004; the preliminary results after the Italian Constitutional Court decision (MayDecember 2009 and comments on cross border infertility treatment for procedures that are still barred.

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“…Irrespective of the ongoing controversy about appropriate number of transferred embryos in assisted reproduction technologies (ART) and, in particular the very high rate of triplet births (1)(2)(3), this new Italian legislation restricted the number of fertilized oocytes in each cycle to three, but obliged the subsequent transfer of all resulting embryos and prohibited freezing of surplus embryos (1)(2)(3). Within these legislative constrains, Italian clinicians must first select the three best retrieved oocytes for insemination, and to freeze the remaining oocytes for use in future cycles (4).…”

mentioning

confidence: 99%