The Effect of Lambda-Cyhalothrin on Root Tip Cytology, Pigment Contents and Antioxidant Defense System of &lt;i&gt;Allium cepa&lt;/i&gt;

Çavuşoğlu, Kültiğin; Gür, Birgül; Yalçın, Emine; Demirtaş, Güray; Çiçek, Figen

doi:10.1508/cytologia.79.95

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…It is suggested that the decrease in GSH levels in the permethrin-treated group is due to the oxidation of GSH during free radical scavenging. Similarly, Çavuşoğlu et al ( 2014 ) found that lambda-cyhalothrin, a pesticide like permethrin, caused an increase in MDA levels in Allium root tip cells. Gabbianelli et al ( 2013 ) reported that administration of 150 mg/kg permethrin increased lipid peroxidation and decreased GSH and CAT activity in rats.…”

Section: Resultsmentioning

confidence: 90%

In-vivo and in-silico studies to identify toxicity mechanisms of permethrin with the toxicity-reducing role of ginger

Himtaş,

Yalçin,

Çavuşoğlu

et al. 2024

Environ Sci Pollut Res

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In this study, the toxic effects of permethrin on Allium cepa L. and the protective role of Zingiber officinale rhizome extract (Zoex) were investigated. In this context, 6 different groups were formed. While the control group was treated with tap water, the groups II and III were treated with 10 µg/mL and 20 µg/mL Zoex, respectively, and the group IV was treated with 100 µg/L permethrin. The protective effect of Zoex against permethrin toxicity was studied as a function of dose, and groups V and VI formed for this purpose were treated with 10 µg/mL Zoex + 100 µg/L permethrin and 20 µg/mL Zoex + 100 µg/L permethrin, respectively. After 72 h of germination, cytogenetic, biochemical, physiological, and anatomical changes in meristematic cells of A. cepa were studied. As a result, permethrin application decreased the mitotic index (MI) and increased the frequency of micronuclei (MN), and chromosomal abnormalities. The increase in malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) and the decrease in glutathione (GSH) indicate that permethrin causes oxidative damage. Compared to the control group, a 68.5% decrease in root elongation (p < 0.05) and an 81.8% decrease (p < 0.05) in weight gain were observed in the permethrin-treated group. It was found that the application of Zoex together with permethrin resulted in regression of all detected abnormalities, reduction in the incidence of anatomical damage, MN and chromosomal aberrations, and improvement in MI rates. The most significant improvement was observed in group VI treated with 20 µg/mL Zoex, and Zoex was also found to provide dose-dependent protection. The toxicity mechanism of permethrin was also elucidated by molecular docking and spectral studies. From the data obtained during the study, it was found that permethrin has toxic effects on A. cepa, a non-target organism, while Zoex plays a protective role by reducing these effects.

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Section: Resultsmentioning

confidence: 90%