The Effect of Lactobacillus Consumption on Human Blood Pressure: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Liu, Jinshu; Zhang, Dan; Guo, Yingze; Cai, Hongwei; Liu, Keyuan; He, Yayu; Liu, Yumo; Guo, Lirong

doi:10.1016/j.ctim.2020.102547

Cited by 10 publications

(11 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present associations between a greater cheese intake and longitudinal decline in diastolic BP, relative increase in fluid intelligence, visuospatial memory, and depressive tendency are mostly consistent with previous interventional, longitudinal, or cross-sectional findings [16,17,19,20,42], and we provide possible speculative mechanisms for these associations. As described in the Methods Section, cross-sectional and interventional studies demonstrated the associations of cheese intake in general or cheese of certain types with lower or decline in BP, and meta-analyses demonstrated the associations of cheese intake with measures that are closely relevant to BP, such as stroke risk, arterial stiffness, and blood lipid [16,17,19,20,42]. In addition, using the same UK Biobank data, a greater cheese intake was shown to be associated with a greater longitudinal retention (less decline) in fluid intelligence [43].…”

Section: Discussionsupporting

confidence: 91%

“…Some diets can lower BP. Among these, lactobacilli, including those of certain types of cheese, are associated with decreased BP [16]. Additionally, a recent middle-sized sample study showed that a greater cheese intake is associated with lower BP [17], probably because peptides with angiotensin-converting enzyme (ACE, which narrows blood vessels and increases BP)-inhibiting or BP-lowering activity have been identified in many cheeses [18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Diastolic Blood Pressure on Brain Structures and Cognitive Functions in Middle and Old Ages: Longitudinal Analyses

Takeuchi

Kawashima

2022

Nutrients

View full text Add to dashboard Cite

Hypertension is a pervasive public health concern due to strong associations with cardiovascular diseases and stroke. Alternatively, the associations between hypertension and the risk of Alzheimer’s disease are complex and recent large sample studies reported positive associations. In this paper, we examine the associations between diastolic blood pressure (BP) and subsequent changes in brain structure and cognitive function over several years by multiple regression analyses (with adjustment for a wide range of potential confounding variables) among a large cohort from the UK Biobank. Higher baseline diastolic BP was associated with a slightly smaller relative increase (relative improvements) in reaction time and a slightly greater reduction in depression scores. Higher baseline diastolic BP was also associated with a greater total gray matter volume (GMV) retention, while aging alone was associated with GMV reduction. White matter microstructural analyses revealed that a greater diastolic BP was associated with reduced longitudinal mean and regional fractional anisotropy, greater increases in mean and regional mean diffusivity, radial diffusivity, and axial diffusivity, a greater decline in mean intracellular volume fraction, and greater increases in mean and regional isotropic volume fraction. These white matter microstructural changes were consistent with those seen in the aging process. Additional analyses revealed a greater cheese intake level at baseline, which is associated with a subsequent decline in diastolic BP and a relative subsequent increase in depressive tendency together with a relative increase in fluid intelligence and visuospatial memory performance. These results are congruent with the view that a higher BP in the aging brain has a complex role.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effects of Diastolic Blood Pressure on Brain Structures and Cognitive Functions in Middle and Old Ages: Longitudinal Analyses

Takeuchi

Kawashima

2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…Consistent with our present findings regarding the lipid profile, an earlier meta-analysis of 15 RCTs found that consumption of Lactobacillus reduced LDL-C (À4.14 mg/dL) and TC (À4.68 mg/dL) [56]. Other meta-analyses have reached inconsistent conclusions with respect to the effect of Lactobacillus supplementation on blood pressure [48,57]. Compared with the earlier research, our meta-analysis has several advantages.…”

Section: Discussionsupporting

confidence: 87%

Effects of Lactobacillus supplementation on glycemic and lipid indices in overweight or obese adults: A systematic review and meta-analysis

Qiu

et al. 2022

Clinical Nutrition

View full text Add to dashboard Cite

“…Assessment of bias was hindered by a general lack of transparency in allocation to treatment and blinding procedure [38]. Despite the aforementioned limitations, study 3 does possess some merits namely a long trial period (12 weeks) allowing time for bacterial colonization to establish [42] and high adherence to the intervention (>95%). Overall, these weaknesses in design suggest that the findings should be interpreted with caution, hence this study was given less weighting.…”

Section: Studymentioning

confidence: 99%

Could Probiotic Supplements Be an Effective Intervention to Reduce Hypertension? A Systematic Literature Review

Harris

2022

OJCAM

View full text Add to dashboard Cite

Introduction: Pathogenesis of high blood pressure or hypertension is associated with microbial imbalance or dysbiosis of the gut microbiome. Previous research suggests probiotic consumption may reduce elevated blood pressure, possibly through manipulation of the gut microbiome, and may offer a future potential therapy for hypertension. Aim:The aim of this research was to critically evaluate current research evidence to assess whether probiotic supplements may reduce high blood pressure and formulate recommendations regarding their use as an intervention to support hypertensive clients in a Nutritional Therapy context. The objectives were to outline the possible association between gut dysbiosis and hypertension, and to explore possible mechanisms by which probiotics may influence blood pressure.Methods: A systematic review of the literature based upon PRISMA protocol was conducted. Four databases were searched: Cochrane Library (Central), CINAHL, Medline and TRIP from January 2014 until July 2020. Five eligible randomised controlled trials, including 453 participants, were identified and critically appraised to assess the quality of their evidence [1].Results: Of the three highest quality studies, two supported probiotic supplements to be effective in reducing blood pressure, one study reported no effect. The remaining two studies were appraised to be of lesser methodological quality so were given less weighting for quality of evidence. This research study found moderate evidence that probiotic supplementation can significantly reduce blood pressure in individuals with borderline hypertension. No effect was reported in normotensives. Conclusion:Probiotic supplementation may offer a convenient and effective adjunct for hypertensives to reduce high blood pressure alongside other dietary/lifestyle/medical interventions.Recommendation: Further large-scale trials of longer duration on hypertensives are recommended to establish functional pathways, bacterial strain, dosage and required timescale.

show abstract

The Effect of Lactobacillus Consumption on Human Blood Pressure: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 10 publications

References 39 publications

Effects of Diastolic Blood Pressure on Brain Structures and Cognitive Functions in Middle and Old Ages: Longitudinal Analyses

Effects of Diastolic Blood Pressure on Brain Structures and Cognitive Functions in Middle and Old Ages: Longitudinal Analyses

Effects of Lactobacillus supplementation on glycemic and lipid indices in overweight or obese adults: A systematic review and meta-analysis

Could Probiotic Supplements Be an Effective Intervention to Reduce Hypertension? A Systematic Literature Review

Contact Info

Product

Resources

About