The effect of lactational mastitis on the macronutrient content of breast milk

B, Say; Dizdar, Evrim Alyamaç; Değirmencioğlu, Halil; Uraş, Nurdan; Sarı, Fatma Nur; Oguz, SS; Canpolat, Fuat Emre

doi:10.1016/j.earlhumdev.2016.03.009

Cited by 20 publications

(22 citation statements)

References 19 publications

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“…In HM, lactose is the main sugar that works as an osmotic regulator [31]. We observed significantly lower lactose concentrations in the HM of SCM mothers.…”

Section: Macronutrient Composition Of Hmmentioning

confidence: 48%

“…To the best of our knowledge, this is the first report to demonstrate the altered levels of macronutrients in the HM of mothers with SCM versus those without in a cohort of European population, although there are a few similar observations from mothers with mastitis of different ethnicities [31,32].…”

Section: Macronutrient Composition Of Hmmentioning

confidence: 72%

“…To the contrary, Say and coworkers observed lower HM energy levels in mastitic mothers from Turkey in a case-control study. The authors postulated this effect as a result of decreased milk synthesis, enhanced permeability of blood-milk barrier and/or increased proteolytic/enzymatic activity [31].…”

Section: Macronutrient Composition Of Hmmentioning

confidence: 99%

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Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth

et al. 2019

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Background: Subclinical mastitis (SCM) is an inflammatory condition of the mammary gland. We examined the effects of SCM on human milk (HM) composition, infant growth, and HM intake in a mother–infant cohort from seven European countries. Methods: HM samples were obtained from 305 mothers at 2, 17, 30, 60, 90, and 120 days postpartum. SCM status was assessed using HM Sodium (Na): Potassium (K) ratio >0.6. Levels of different macro- and micronutrients were analyzed in HM. Results: SCM prevalence in the first month of lactation was 35.4%. Mean gestational age at delivery was lower and birth by C-section higher in SCM mothers (p ≤ 0.001). HM concentrations of lactose, DHA, linolenic acid, calcium, and phosphorous (p < 0.05 for all) was lower, while total protein, alpha-lactalbumin, lactoferrin, albumin, arachidonic acid to DHA ratio, n-6 to n-3 ratio and minerals (iron, selenium, manganese, zinc, and copper) were higher (p < 0.001 for all) in mothers with SCM. There were no differences in infant growth and HM intake between non-SCM and SCM groups. Conclusion: We document, for the first time, in a large European standardized and longitudinal study, a high prevalence of SCM in early lactation and demonstrate that SCM is associated with significant changes in the macro- and micronutrient composition of HM. Future studies exploring the relation of SCM with breastfeeding behaviors and developmental outcomes are warranted.

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“…In HM, lactose is the main sugar that works as an osmotic regulator [31]. We observed significantly lower lactose concentrations in the HM of SCM mothers.…”

Section: Macronutrient Composition Of Hmmentioning

confidence: 48%

Section: Macronutrient Composition Of Hmmentioning

confidence: 72%

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Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth

et al. 2019

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“…Las mastitis son más frecuente en la segunda y tercera semana posparto (Creasy et al, 2004), y la mayoría de los estudios indican que el 75-95% de los casos ocurren en las primeras 12 semanas (Walker et al, 1999;Say et al, 2016). Sin embargo, puede producirse en cualquier momento de la lactancia.…”

Section: Mastitisunclassified

“…Hay un estudio realizado a 30 mujeres (15 con mastitis y 15 control) en el que se observa una disminución de la producción de leche así como de la grasa, los carbohidratos y la energía en la leche de las madres con mastitis (Say et al, 2016). Por otro lado, un estudio realizado en mujeres peruanas (38 controles y 36 mastitis) muestra que no hubo diferencias significativas en cuanto al volumen de la leche ni tampoco en la concentración de proteínas totales (Zavaleta et al, 1995).…”

Section: Figura 21 Representación Esquemática Del Epitelio Y Los Conunclassified

Efecto de los arándanos sobre el estado oxidativo de la leche en madres con mastitis

García¹

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A Hermelinda, gracias por tu absoluta disponibilidad, y por tu esfuerzo y trabajo en mis ausencias en la farmacia.A todas las madres que generosamente contribuyeron en este estudio con su participación. 12A mi amiga Sandra Brunori, gracias por la portada, has captado perfectamente la idea que yo llevaba, ¡¡¡me encanta!!! A mis amigas, María Segarra y Teresa García, porque sois la familia que se escoge, por vuestros ánimos, porque siempre estáis cuando os necesito, y habéis compartido conmigo todo este camino. Esta tesis ha dado para varios "Charquitos" y un viaje a París.A mi prima, la Dra. Marta Pilar Montañez por tu disposición, dedicación y trabajo para que esta tesis tomara forma. Si no hubiese sido por ti, aún estaría peleándome con las sangrías, los encabezados y los pies de página. Gracias por tus correcciones, por tus sabios consejos, cada segundo hablado contigo lo he aprovechado; y por acompañarme en la recta final de esta aventura.A mis hermanos Manuel y Catalina, por estar ahí siempre y cuidar de mis hijos cuando lo he necesitado.A mi hermana Teresa, con la que comparto profesión, gracias por haber supervisado mi trabajo, por saber escuchar, por tu generosidad y ayuda incondicionales en todos los momentos importantes de mi vida. Sabes que esta tesis lleva también tu nombre.A Mónica, mi amiga y compañera de vida, por animarme y apoyarme en todos mis proyectos, especialmente en este. Gracias por estar siempre a mi lado.A mis hijos Diego y Balma, porque con Diego descubrí la lactancia y con Balma la sigo disfrutando. Vosotros habéis sido el mejor motivo para terminarla.

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The microbiology and treatment of human mastitis

Angelopoulou

Field

Ryan

et al. 2018

Med Microbiol Immunol

104

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Mastitis, which is generally described as an inflammation of breast tissue, is a common and debilitating disease which frequently results in the cessation of exclusive breastfeeding and affects up to 33% of lactating women. The condition is a primary cause of decreased milk production and results in organoleptic and nutritional alterations in milk quality. Recent studies employing culture-independent techniques, including metagenomic sequencing, have revealed a loss of bacterial diversity in the microbiome of mastitic milk samples compared to healthy milk samples. In those infected, the pathogens Staphylococcus aureus, Staphylococcus epidermidis and members of corynebacteria have been identified as the predominant etiological agents in acute, subacute and granulomatous mastitis, respectively. The increased incidence of antibiotic resistance in the causative species is also a key cause of concern for treatment of the disease, thus leading to the need to develop novel therapies. In this respect, probiotics and bacteriocins have revealed potential as alternative treatments.

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The effect of lactational mastitis on the macronutrient content of breast milk

Cited by 20 publications

References 19 publications

Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth

Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth

Efecto de los arándanos sobre el estado oxidativo de la leche en madres con mastitis

The microbiology and treatment of human mastitis

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