The effect of l-carnitine supplementation on mortality and clinical outcomes in ventilator-dependent critically ill patients with obesity and COVID-19: Protocol for a randomized double-blind placebo-controlled trial

Unveiling Pathophysiological Insights: Serum Metabolic Dysregulation in Acute Respiratory Distress Syndrome Patients with Acute Kidney Injury

“…Disturbance in transportation results in the accumulation of unoxidized fatty acyl-CoA molecules in the cytosol that are believed to hamper the urea cycle, leading to ammonia accumulation. 40,41 Similarly, glutamate, which is also responsible for ammonia transportation, eventually causes hyperammonemia when it is in a lower concentration in the blood. Yelamanchi et al 42 explained that deficiency of glutamate and the enzymes responsible for its metabolism are the main causes of hyperammonemia.…”

“…Acetylcarnitine is also involved in the beta-oxidation of fatty acids, which facilitates the translocation of heavy acyl-CoA residues from the cytoplasm to the mitochondrial matrix, where beta-oxidation and energy production take place. Disturbance in transportation results in the accumulation of unoxidized fatty acyl-CoA molecules in the cytosol that are believed to hamper the urea cycle, leading to ammonia accumulation. , Similarly, glutamate, which is also responsible for ammonia transportation, eventually causes hyperammonemia when it is in a lower concentration in the blood. Yelamanchi et al explained that deficiency of glutamate and the enzymes responsible for its metabolism are the main causes of hyperammonemia.…”