Abstract:The effect of intracellular level of GSH on the cytotoxicity and interaction of four environmentally relevant metals arsenic, cadmium, mercury and lead (As, Cd, Hg, and Pb) was investigated. L-Buthionine Sulfoximine (LBSO) was used to inhibit the intracellular level of GSH in MCF 7 cells. Both individual and combined cytotoxicities of the four metals on the cells were assayed by spectrofluorometric counting of the surviving cells after 24-hour exposure. Exposure of the cells to three of the studied metals: As,… Show more
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