The effect of l-arginine on bladder dysfunction following ovariectomy in a rabbit model

Abstract

Ovariectomy appreciably reduced bladder contractility. Treatment with L-arginine reversed the ovariectomy-induced bladder dysfunction. Decreased bladder contractile response was observed in the early days following ovariectomy.

Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure

“…We did not, however, observe any changes in the hypothalamic expression of Sh2b, Socs3, and Ptp1b by leucine deprivation (data not shown). Recent studies have demonstrated that Rho kinase (ROCK)1, in which the activity is influenced by nutritional status (51,52), increases phosphorylation of JAK2 and downstream activation of STAT3 to regulate leptin action (45). A possible role for ROCK1 in connecting leucine deprivation with the leptin pathway will be studied in the future.…”